Matches in SemOpenAlex for { <https://semopenalex.org/work/W288777787> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W288777787 endingPage "263" @default.
- W288777787 startingPage "255" @default.
- W288777787 abstract "Mouse hepatitis virus type 3 infection leads to various types of evolution according to strain, age and immune status of animals-1, 2. Three types of viral sensitivity were observed: resistance, full susceptibility and semisusceptibility. The latter is characterized by a chronic disease with occurrence of paralysis, immunodepression, and viral persistency since MHV3 can be recovered during the first three months postinfection in most animals from brain, liver, spleen and lymph nodes1. During the first four days of infection, virus was recovered from the liver of resistant as well as susceptible strain mice. In resistant A/J strain mice, viral titers were consistently low whereas titers greater than 104 were always found in susceptible C57BL/6 animals. In the resistant mouse strain, virus was cleared from liver, brain and serum within seven days. In contrast, virus continued to replicate until death in susceptible animals. Immunosuppressive treatment, however, can abogate the resistance displayed by adult A/J mice, leading to an acute disease and to death. Protection of susceptible newborn mice against MHV3 infection requires the transfer of several cell populations originating from syngenic adult donors: adherent spleen cells, T lymphocytes and a third population present in the non-adherent spleen cell fraction as well as in peritoneal exudate and in bone marrow cells2, 3. Resistance to the acute disease was also correlated with viral replication in hepatocytes4, in embryonic fibroblasts5 and in peritoneal exudate cells2, 6, 7. Recent work suggested that at least two complementary mechanisms were required to confer resistance to MHV3: resistance genes operating at the macrophage level and cells capable to elicit an efficient immune response8." @default.
- W288777787 created "2016-06-24" @default.
- W288777787 creator A5031432740 @default.
- W288777787 creator A5076557765 @default.
- W288777787 date "1987-01-01" @default.
- W288777787 modified "2023-10-16" @default.
- W288777787 title "Characterization of a Non-Pathogenic MHV3 Variant Derived from a Persistently Infected Lymphoid Cell Line" @default.
- W288777787 cites W1509214713 @default.
- W288777787 cites W1532900807 @default.
- W288777787 cites W1868544281 @default.
- W288777787 cites W2001745911 @default.
- W288777787 cites W2023196220 @default.
- W288777787 cites W2101108802 @default.
- W288777787 cites W2131666887 @default.
- W288777787 cites W2410249347 @default.
- W288777787 cites W4313310132 @default.
- W288777787 cites W4313310188 @default.
- W288777787 doi "https://doi.org/10.1007/978-1-4684-1280-2_30" @default.
- W288777787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2829534" @default.
- W288777787 hasPublicationYear "1987" @default.
- W288777787 type Work @default.
- W288777787 sameAs 288777787 @default.
- W288777787 citedByCount "3" @default.
- W288777787 countsByYear W2887777872016 @default.
- W288777787 crossrefType "book-chapter" @default.
- W288777787 hasAuthorship W288777787A5031432740 @default.
- W288777787 hasAuthorship W288777787A5076557765 @default.
- W288777787 hasConcept C140704245 @default.
- W288777787 hasConcept C142724271 @default.
- W288777787 hasConcept C159047783 @default.
- W288777787 hasConcept C203014093 @default.
- W288777787 hasConcept C2522874641 @default.
- W288777787 hasConcept C2779134260 @default.
- W288777787 hasConcept C2779193416 @default.
- W288777787 hasConcept C2779567548 @default.
- W288777787 hasConcept C2780931953 @default.
- W288777787 hasConcept C2908647359 @default.
- W288777787 hasConcept C3008058167 @default.
- W288777787 hasConcept C524204448 @default.
- W288777787 hasConcept C71924100 @default.
- W288777787 hasConcept C86803240 @default.
- W288777787 hasConcept C8891405 @default.
- W288777787 hasConcept C99454951 @default.
- W288777787 hasConceptScore W288777787C140704245 @default.
- W288777787 hasConceptScore W288777787C142724271 @default.
- W288777787 hasConceptScore W288777787C159047783 @default.
- W288777787 hasConceptScore W288777787C203014093 @default.
- W288777787 hasConceptScore W288777787C2522874641 @default.
- W288777787 hasConceptScore W288777787C2779134260 @default.
- W288777787 hasConceptScore W288777787C2779193416 @default.
- W288777787 hasConceptScore W288777787C2779567548 @default.
- W288777787 hasConceptScore W288777787C2780931953 @default.
- W288777787 hasConceptScore W288777787C2908647359 @default.
- W288777787 hasConceptScore W288777787C3008058167 @default.
- W288777787 hasConceptScore W288777787C524204448 @default.
- W288777787 hasConceptScore W288777787C71924100 @default.
- W288777787 hasConceptScore W288777787C86803240 @default.
- W288777787 hasConceptScore W288777787C8891405 @default.
- W288777787 hasConceptScore W288777787C99454951 @default.
- W288777787 hasLocation W2887777871 @default.
- W288777787 hasLocation W2887777872 @default.
- W288777787 hasOpenAccess W288777787 @default.
- W288777787 hasPrimaryLocation W2887777871 @default.
- W288777787 hasRelatedWork W1487857142 @default.
- W288777787 hasRelatedWork W1512647329 @default.
- W288777787 hasRelatedWork W1568351975 @default.
- W288777787 hasRelatedWork W1944386703 @default.
- W288777787 hasRelatedWork W2003416812 @default.
- W288777787 hasRelatedWork W2036107469 @default.
- W288777787 hasRelatedWork W2064760266 @default.
- W288777787 hasRelatedWork W2081358646 @default.
- W288777787 hasRelatedWork W2085162533 @default.
- W288777787 hasRelatedWork W2781693618 @default.
- W288777787 isParatext "false" @default.
- W288777787 isRetracted "false" @default.
- W288777787 magId "288777787" @default.
- W288777787 workType "book-chapter" @default.