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• W2887809138 abstract "Dramatic advances in our understanding of the molecular pathophysiology of cancer, along with a rapidly expanding portfolio of molecular targeted drugs, have led to a paradigm shift toward personalized, biomarker-driven cancer treatment. Here, we report the 2-year experience of the Comprehensive Cancer Center Freiburg Molecular Tumor Board (MTB), one of the first interdisciplinary molecular tumor conferences established in Europe. The role of the MTB is to recommend personalized therapy for patients with cancer beyond standard-of-care treatment.This retrospective case series includes 198 patients discussed from March 2015 through February 2017. The MTB guided individual molecular diagnostics, assessed evidence of actionability of molecular alterations, and provided therapy recommendations, including approved and off-label treatments as well as available matched clinical trials.The majority of patients had metastatic solid tumors (73.7%), mostly progressive (77.3%) after a mean of 2.0 lines of standard treatment. Diagnostic recommendations resulted in 867 molecular diagnostic tests for 172 patients (five per case), including exome analysis in 36 cases (18.2%). With a median turnaround time of 28 days, treatment recommendations were given to 104 patients (52.5%). These included single-agent targeted therapies (42.3%), checkpoint inhibitors (37.5%), and combination therapies (18.3%). Treatment recommendations were implemented in 33 of 104 patients (31.7%), of whom 19 (57.6%) showed stable disease or partial response, including 14 patients (7.1% of the entire population) receiving off-label treatments.Personalized extended molecular-guided patient care is effective for a small but clinically meaningful proportion of patients in challenging clinical situations. Limited access to targeted drugs, lack of trials, and submission at late disease stage prevents broader applicability, whereas genome-wide analyses are not a strict requirement for predictive molecular testing." @default.
• W2887809138 created "2018-08-22" @default.
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• W2887809138 date "2018-11-01" @default.
• W2887809138 modified "2023-10-02" @default.
• W2887809138 title "Personalized Clinical Decision Making Through Implementation of a Molecular Tumor Board: A German Single-Center Experience" @default.
• W2887809138 cites W1846586690 @default.
• W2887809138 cites W1914351667 @default.
• W2887809138 cites W1926851645 @default.
• W2887809138 cites W1940682904 @default.
• W2887809138 cites W1966722003 @default.
• W2887809138 cites W1967220865 @default.
• W2887809138 cites W1968048579 @default.
• W2887809138 cites W1971061361 @default.
• W2887809138 cites W1980740976 @default.
• W2887809138 cites W1987507232 @default.
• W2887809138 cites W2003984225 @default.
• W2887809138 cites W2009569945 @default.
• W2887809138 cites W2009720434 @default.
• W2887809138 cites W2014881369 @default.
• W2887809138 cites W2015885891 @default.
• W2887809138 cites W2049553585 @default.
• W2887809138 cites W2059145105 @default.
• W2887809138 cites W2097331151 @default.
• W2887809138 cites W2104347254 @default.
• W2887809138 cites W2105660237 @default.
• W2887809138 cites W2111326065 @default.
• W2887809138 cites W2114029728 @default.
• W2887809138 cites W2118151336 @default.
• W2887809138 cites W2119754956 @default.
• W2887809138 cites W2121545342 @default.
• W2887809138 cites W2122732537 @default.
• W2887809138 cites W2123507520 @default.
• W2887809138 cites W2128542677 @default.
• W2887809138 cites W2133296598 @default.
• W2887809138 cites W2137526110 @default.
• W2887809138 cites W2146512944 @default.
• W2887809138 cites W2150575159 @default.
• W2887809138 cites W2154866190 @default.
• W2887809138 cites W2167202878 @default.
• W2887809138 cites W2169456326 @default.
• W2887809138 cites W2169853174 @default.
• W2887809138 cites W2171504383 @default.
• W2887809138 cites W2193403647 @default.
• W2887809138 cites W223909586 @default.
• W2887809138 cites W2253928581 @default.
• W2887809138 cites W2256016639 @default.
• W2887809138 cites W2291298003 @default.
• W2887809138 cites W2301695049 @default.
• W2887809138 cites W2344922370 @default.
• W2887809138 cites W2364794827 @default.
• W2887809138 cites W2477057044 @default.
• W2887809138 cites W2526188806 @default.
• W2887809138 cites W2530590137 @default.
• W2887809138 cites W2534249763 @default.
• W2887809138 cites W2536396512 @default.
• W2887809138 cites W2559382297 @default.
• W2887809138 cites W2560367415 @default.
• W2887809138 cites W2566723262 @default.
• W2887809138 cites W2572174216 @default.
• W2887809138 cites W2587768298 @default.
• W2887809138 cites W2601520864 @default.
• W2887809138 cites W2620581814 @default.
• W2887809138 cites W2622985700 @default.

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