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- W2887831283 abstract "A bioequivalence of tablets (Yuhan corporation) and tablets (Kuhnil Pharm. Co., Ltd.) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Single 200 mg dose of etodolac of each medicine was administered orally to 24 healthy male volunteers. This study was performed in a crossover design. Concentrations of etodolac in human plasma were monitored by a high-performance liquid chromatography. (the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. (maximum plasma drug concentration) and (time to reach ) were compiled from the plasma concentration-time data. Analysis of variance was performed using logarithmically transformed and . No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the ratio and the ratio for were 1.01-1.10 and 0.87-1.06, respectively. This study demonstrated a bioequivalence of and with respect to the rate and extent of absorption." @default.
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- W2887831283 date "2004-08-20" @default.
- W2887831283 modified "2023-09-26" @default.
- W2887831283 title "Bioequivalence of EtodolTMTablet to KuhnillodineTMTablet (Micronized Etodolac 200 mg)" @default.
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- W2887831283 doi "https://doi.org/10.4333/kps.2004.34.4.319" @default.
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