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• W2887833771 abstract "An adjunctive topical therapy with gentamicin-sponges to systemic antibiotic therapy might improve the healing of infected diabetic foot ulcers (DFUI).Single-center, investigator-blinded pilot study, randomizing (1:1) the gentamicin-sponge with systemic antibiotic versus systemic antibiotics alone for patients with DFUI.We included 88 DFUI episodes with 43 patients in the gentamicin-sponge arm and 45 in the control arm. Overall, 64 (64/88; 73%) witnessed total clinical cure, 13 (15%) significant improvement, and 46 (52%) showed total eradication of all pathogens at the final visit. Regarding final clinical cure, there was no difference in favour of the gentamicin-sponges (26/45 vs. 31/43; p = 0.16). However, the gentamicin-sponge arm tended to a more rapid healing. In multivariate analysis adjusting for the case-mix, the variable gentamicin-sponge was not significantly associated with cure and improvement. Gentamicin-sponges were very well tolerated, without any attributed adverse events.The gentamicin-sponge was very well tolerated, but did not significantly influence overall cure.ClinicalTrials.gov ( NCT01951768 ). Date 2 April 2013." @default.
• W2887833771 created "2018-08-22" @default.
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• W2887833771 date "2018-08-02" @default.
• W2887833771 modified "2023-10-11" @default.
• W2887833771 title "A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection" @default.
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• W2887833771 doi "https://doi.org/10.1186/s12879-018-3253-z" @default.
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