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- W2887845188 abstract "Background and Purpose— To study cerebrovascular autoregulation and its impact on clinical course in patients with impending malignant middle cerebral artery infarction, we used invasive multimodal neuromonitoring, including measurement of cerebral perfusion pressure, tissue oxygen pressure, and microdialysis. Methods— Fifteen patients with a stroke that involved >50% of the middle cerebral artery territory were included. Probes were placed into the ipsilateral frontal lobe. Autoregulation was assessed by calculation of the cerebral perfusion pressure–oxygen reactivity index (COR) and the correlation coefficient (R) of cerebral perfusion pressure and tissue oxygen pressure at 24 and 72 hours after stroke. Results— COR and R at 24 hours after stroke were higher in the 8 patients with a malignant course (ie, massive edema formation) compared with the 7 patients with a benign course (COR, 1.99±1.46 versus 0.68±0.29; R, 0.49±0.28 versus 0.06±0.31; P<0.05), indicating impaired autoregulation in the malignant c..." @default.
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- W2887845188 date "2007-01-01" @default.
- W2887845188 modified "2023-09-24" @default.
- W2887845188 title "Identification and Clinical Impact of Impaired Cerebrovascular Autoregulation in Patients With Malignant Middle Cerebral Artery Infarction" @default.
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