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• W2887881235 startingPage "1544" @default.
• W2887881235 abstract "Brain metastasis (BM) is the primary contributor to mortality in non‐small cell lung cancer ( NSCLC ) patients. Although the findings of NSCLC genetic sequencing studies suggest the potential for personalizing therapeutic approaches, the genetic profiles and underlying mechanisms of BM progression remain poorly understood. Here, we investigated the genetic profiles of brain metastases from NSCLC in six patients with primary tumors and corresponding BM samples via whole exome sequencing and targeted panel sequencing. We have demonstrated considerable genetic heterogeneity between primary lung cancer and corresponding brain metastases specimens. High‐frequency mutations were found in NOTCH 2 , NOTCH 2 NL , FANCD 2 , EGFR , and TP 53 . Additionally, EGFR and TP 53 consistently exhibited high frequencies of mutation between primary tumors and corresponding brain metastases. The implication is that most of the genetic alterations may be acquired or lost during malignant progression, and the stable EGFR and TP 53 mutational status between paired primary tumors and metastatic sites confirms that most mutations detected on analysis of the primary tumor or metastases are sufficient for clinical decision‐making, and suggest there is no need to re‐biopsy recurrent tumors or metastases for most NSCLC patients." @default.
• W2887881235 created "2018-08-22" @default.
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• W2887881235 date "2018-08-30" @default.
• W2887881235 modified "2023-10-06" @default.
• W2887881235 title "Characterization of genetic alterations in brain metastases from non‐small cell lung cancer" @default.
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• W2887881235 doi "https://doi.org/10.1002/2211-5463.12501" @default.
• W2887881235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6120240" @default.
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• W2887881235 hasPublicationYear "2018" @default.
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