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- W2887883871 abstract "Background and Purpose— Notch signaling activity regulates arteriogenesis. Presenilin 1 (PS1) mediates Notch signaling activity via cleavage of Notch, liberating Notch intracellular domain (NICD). We tested the hypothesis that simvastatin enhances arteriogenesis after stroke by increasing PS1 activation of the Notch signaling pathway. Methods— Rats were subjected to middle cerebral artery occlusion (MCAo) and treated with or without simvastatin (1 mg/kg) starting 24 hours after stroke and daily for 7 days; they were euthanized 14 days after stroke. Immunostaining, Western blot, and real-time polymerase chain reaction assays were performed. Results— Simvastatin significantly increased arterial diameter, density, and vascular smooth muscle cell proliferation, and upregulated PS1, Notch1, and NICD expression in the ischemic border tissue and in the cerebral arteries compared with MCAo control rats, respectively. However, simvastatin did not increase arteriogenesis, PS1, and NICD expression in sham control an..." @default.
- W2887883871 created "2018-08-22" @default.
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- W2887883871 date "2009-01-01" @default.
- W2887883871 modified "2023-09-23" @default.
- W2887883871 title "Simvastatin Increases Notch Signaling Activity and Promotes Arteriogenesis After Stroke" @default.
- W2887883871 hasPublicationYear "2009" @default.
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