FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887907393> ?p ?o ?g. }

• W2887907393 abstract "INTRODUCTION:Traditional system of medicine is one of the centuries old practice and longservingcompanion to humankind in the fight against disease and in leading a healthy life.Indigenous people have been using the unique approach of their traditional system ofmedicine for centuries and among the most renowned are the Chinese, Indian, Africansystems of medicine. Traditional medicine refers to any ancient and culturally basedhealthcare practice differing from scientific medicine and is largely transmitted orally bycommunities of different cultures.[1] The World Health Organization (WHO) observes thatit is difficult to assign one definition to the broad range of characteristics and elements oftraditional medicine, but that a working definition is essential. It thus concludes that thetraditional medicines ‘‘[include] diverse health practices, approaches, knowledge andbeliefs incorporating plant, animal and mineral based medicines, spiritual therapies,manual techniques and exercises applied singularly or in combination to maintain wellbeing,as well as to treat, diagnose or prevent illness. AIM:The aim of Novel Drug Delivery System is to provide a therapeutic amountof drug to the appropriate site in the body to accomplish promptly and thenmaintain the desired drug concentration. The drug- delivery system should deliverdrug at a rate control by the necessarily of the body over a specified term of treatment. 2. To prepare and evaluate Transdermal Patch of Aqueous extract ofAzadirachta indica A. juss using different polymers OBJECTIVE: 1. To convert the herbal extract into a novel dosage form2. To provide a direct entry of aqueous extract into the systemic circulation to givesustained action3. To develop a novel topical formulation of aqueous extract of neem leaves for theeffective treatment of Skin infections SUMMARY: The various formulation parameters, Drug-Polymer ratios and permeation enhancerswere optimized to get thin, transparent, smooth, stable and high permeable transdermal patches.The FTIR graphs of drug, excipients and formulations showed that there is no extrapeak (or) broadening of peaks were observed and thus it indicates that there is no incompatibilitybetween drug and excipients.From the optimization, best 2 formulations P2 & S5 were selected based on physicochemical evaluation and in vitro drug diffusion study0.3ml of glycerin was added as plasticizer to produce a flexible patch without havingmajor influence on their diffusion property. If the amount exceeds, the film loses its flexibilityand become stiff.The plasticizer diffuses through the patch and softens the polymer particles. Thissoftening promotes latex coalescence and patch formation.All the six batches were evaluated for Percentage Moisture uptake, PercentageMoisture content, Thickness, Folding Endurance, Percentage Drug content, Percent Elongation,Tensile strength and Adhesive strength.The formulations P2 & S5 showed maximum % Moisture uptake, Moisture content,Thickness, folding endurance, % Drug content, Percent elongation, Tensile strengthNo significant difference in drug content was observed between the patches amongthe six formulations. This indicates the homogenous dispensing of drug during the patchpreparation. CONCLUSION: The ex vivo studies results showed 61.01% of drug diffusion at the end of 8 h. Itconcluded the controlled diffusion property of through the skin. The stability studies results showed that there is no significant change from its initial naturetill the period of three months at 40˚C ±2˚C/75 5% RH.The present work has achieved the objectives of formulation of transdermal patch ofAqueous extract of Azadirachta indica by using different polymers. The diffusion kineticsconfirms that the formulation followed zero order, non-fickian diffusion model." @default.
• W2887907393 created "2018-08-22" @default.
• W2887907393 creator A5018792470 @default.
• W2887907393 date "2017-10-01" @default.
• W2887907393 modified "2023-09-27" @default.
• W2887907393 title "Formulation and Evaluation of Transdermal Patch of AqueousExtract of Azadirachta Indica A Juss" @default.
• W2887907393 hasPublicationYear "2017" @default.
• W2887907393 type Work @default.
• W2887907393 sameAs 2887907393 @default.
• W2887907393 citedByCount "0" @default.
• W2887907393 crossrefType "dissertation" @default.
• W2887907393 hasAuthorship W2887907393A5018792470 @default.
• W2887907393 hasConcept C127413603 @default.
• W2887907393 hasConcept C142724271 @default.
• W2887907393 hasConcept C160735492 @default.
• W2887907393 hasConcept C17744445 @default.
• W2887907393 hasConcept C18903297 @default.
• W2887907393 hasConcept C199539241 @default.
• W2887907393 hasConcept C204787440 @default.
• W2887907393 hasConcept C205679159 @default.
• W2887907393 hasConcept C2776556288 @default.
• W2887907393 hasConcept C2780035454 @default.
• W2887907393 hasConcept C2781035296 @default.
• W2887907393 hasConcept C2988170871 @default.
• W2887907393 hasConcept C514011633 @default.
• W2887907393 hasConcept C55587333 @default.
• W2887907393 hasConcept C556039675 @default.
• W2887907393 hasConcept C55958113 @default.
• W2887907393 hasConcept C71924100 @default.
• W2887907393 hasConcept C86803240 @default.
• W2887907393 hasConcept C98274493 @default.
• W2887907393 hasConceptScore W2887907393C127413603 @default.
• W2887907393 hasConceptScore W2887907393C142724271 @default.
• W2887907393 hasConceptScore W2887907393C160735492 @default.
• W2887907393 hasConceptScore W2887907393C17744445 @default.
• W2887907393 hasConceptScore W2887907393C18903297 @default.
• W2887907393 hasConceptScore W2887907393C199539241 @default.
• W2887907393 hasConceptScore W2887907393C204787440 @default.
• W2887907393 hasConceptScore W2887907393C205679159 @default.
• W2887907393 hasConceptScore W2887907393C2776556288 @default.
• W2887907393 hasConceptScore W2887907393C2780035454 @default.
• W2887907393 hasConceptScore W2887907393C2781035296 @default.
• W2887907393 hasConceptScore W2887907393C2988170871 @default.
• W2887907393 hasConceptScore W2887907393C514011633 @default.
• W2887907393 hasConceptScore W2887907393C55587333 @default.
• W2887907393 hasConceptScore W2887907393C556039675 @default.
• W2887907393 hasConceptScore W2887907393C55958113 @default.
• W2887907393 hasConceptScore W2887907393C71924100 @default.
• W2887907393 hasConceptScore W2887907393C86803240 @default.
• W2887907393 hasConceptScore W2887907393C98274493 @default.
• W2887907393 hasLocation W28879073931 @default.
• W2887907393 hasOpenAccess W2887907393 @default.
• W2887907393 hasPrimaryLocation W28879073931 @default.
• W2887907393 hasRelatedWork W1587149123 @default.
• W2887907393 hasRelatedWork W2275019760 @default.
• W2887907393 hasRelatedWork W2782562272 @default.
• W2887907393 hasRelatedWork W2782662776 @default.
• W2887907393 hasRelatedWork W2782695014 @default.
• W2887907393 hasRelatedWork W2783013439 @default.
• W2887907393 hasRelatedWork W2783064870 @default.
• W2887907393 hasRelatedWork W2783424054 @default.
• W2887907393 hasRelatedWork W2783517338 @default.
• W2887907393 hasRelatedWork W2783861488 @default.
• W2887907393 hasRelatedWork W2784013585 @default.
• W2887907393 hasRelatedWork W2784095951 @default.
• W2887907393 hasRelatedWork W2888049903 @default.
• W2887907393 hasRelatedWork W2893610036 @default.
• W2887907393 hasRelatedWork W2955820824 @default.
• W2887907393 hasRelatedWork W1869379909 @default.
• W2887907393 hasRelatedWork W2185082107 @default.
• W2887907393 hasRelatedWork W2185653705 @default.
• W2887907393 hasRelatedWork W2188683788 @default.
• W2887907393 hasRelatedWork W2550854035 @default.
• W2887907393 isParatext "false" @default.
• W2887907393 isRetracted "false" @default.
• W2887907393 magId "2887907393" @default.
• W2887907393 workType "dissertation" @default.