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- W2887913609 abstract "Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important contributor to population morbidity and mortality. An arrhythmia that is particularly common in the elderly, AF is growing in prevalence with the aging of the population. Our understanding of the basic mechanisms that govern AF occurrence and persistence has been increasing rapidly. This article reviews the basic pathophysiology of AF over a broad range of levels, touching on the tissue mechanisms that maintain the arrhythmia, the relationship between clinical presentation and basic mechanisms, ion channel and transporter abnormalities that lead to ectopic impulse formation, basic models and tissue determinants of reentry, ion channel determinants of reentry, the nature and roles of electric and structural remodeling, autonomic neural components, anatomic factors, interactions between atrial and ventricular functional consequences of AF, and the basic determinants of atrial thromboembolism. We then review the potential..." @default.
- W2887913609 created "2018-08-22" @default.
- W2887913609 date "1996-08-02" @default.
- W2887913609 modified "2023-09-26" @default.
- W2887913609 title "Atrial Fibrillation: Pathophysiology" @default.
- W2887913609 doi "https://doi.org/10.1093/eurheartj/17.suppl_5.522" @default.
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