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- W2887957636 abstract "Small molecules that interfere with nucleic acid are widely used in chemotherapy, however, improved delivery approaches are required to improve anti-tumor outcomes. Here, we present the development of an ultrasound-activatable porphyrin-phospholipid-liposome (pp-lipo) that responds to low intensity focused ultrasound (LIFU) for sonodynamic therapy (SDT). The pp-lipo is constructed by incorporating a small proportion of porphyrin (pyropheophorbide) conjugated lipid into a liposome formulation. This enables sonosensitization-induced lipid oxidation and efficient disruption of liposomes to release loaded doxorubicin (Dox). This results in increased Dox nuclear subcellular location and cytotoxicity in cancer cells in vitro upon pp-lipo exposure to LIFU. Following intravenous administration, LIFU enhanced deposition of Dox within tumor tissue, suppressed tumor growth, and also increased porphyrin near infrared tumor fluorescence. Thus, pp-lipo is a versatile carrier that can be extended to many ultrasound-controllable drug delivery applications." @default.
- W2887957636 created "2018-08-22" @default.
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- W2887957636 date "2018-09-01" @default.
- W2887957636 modified "2023-09-29" @default.
- W2887957636 title "Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins" @default.
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- W2887957636 doi "https://doi.org/10.1016/j.jconrel.2018.07.048" @default.
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