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- W2887962783 abstract "Epigenetics modulated tissue-specific gene expression during the onset of type 1 and type 2 diabetes and their complications.We searched the PubMed recent studies about the main epigenetic tags involved in type 1 and type 2 diabetes onset and their clinical complications. PubMed studies about the epigenetic tags involved in type 1 and 2 diabetes onset was searched.The epigenetic methylation maps of cord blood samples highlighted differences in the methylation status of CpG sites within the MHC genes between carriers of diabetes type 1 DR3-DQ2 and DR4-DQ8 risk haplotypes. β cell-derived unmethylated INS DNA showed the decline of β-cell mass preserving insulin secretion. Differentially methylated regions in pancreatic islets from type 2 diabetes covered PDX1, TCF7L2, and ADCY5 promoters during islet dysfunction. The recruitment of SET7 and SUV39H1 histone methyltransferases and LSD-1 lysine-specific demethylase-1 at NF-kβ-p65 promoter in vascular cells was involved in coronary heart disease. Neutrophil extracellular trap, activated by protein arginine deiminase-4, impaired wound healing from diabetic foot ulcers. MiR-199a-3p over-expression induced coagulative cascade, swelling and pain by a down-regulation of SERPIN-E2 in diabetic peripheral neuropathy. A DNA hypo-methylation and histone hyper-acetylation at MIOX promoter led an overexpression of ROS, fibronectin, HIF-1α, and NOX-4 associated with diabetic tubulopathy. A hypo-methylation of H3K4 at SOD2 promoter by LSD-1 increased ROS causing diabetic retinopathy.Epigenetics played a relevant role in prevention, diagnosis, and treatment of diabetes." @default.
- W2887962783 created "2018-08-22" @default.
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- W2887962783 date "2018-11-01" @default.
- W2887962783 modified "2023-09-27" @default.
- W2887962783 title "Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes" @default.
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- W2887962783 doi "https://doi.org/10.1016/j.jdiacomp.2018.08.012" @default.
- W2887962783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30190170" @default.
- W2887962783 hasPublicationYear "2018" @default.
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