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- W2887964614 abstract "Background Insulin modulates sympathetic vasoconstriction, but the mechanisms underlying this effect are not completely elucidated. We have recently investigated the insulin effect on the α1- and α2-adrenergic vasoconstriction pathway, where it is still conflicting with the possible insulin influence on the β-adrenergic vasodilator pathway. The aim of the present study was to investigate this issue. Methods and Results The study was performed on the forearm of healthy humans, and all test substances were infused into the brachial artery at systemically ineffective rates. In five subjects, we evaluated isoproterenol-induced vasodilation (1, 3, 6, and 9 ng·kg−1·min−1) both under control conditions and during insulin infusion (0.05 mU·kg−1·min−1). In another group of five subjects, we tested whether the vasorelaxant effect of sodium nitroprusside (1, 2, 4, and 8 ng·kg−1·min−1) was modified by insulin. Moreover, to explore whether the interaction between insulin and forearm β-adrenergic pathway participates i..." @default.
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- W2887964614 date "1996-04-01" @default.
- W2887964614 modified "2023-09-28" @default.
- W2887964614 title "Insulin Modulation of β-Adrenergic Vasodilator Pathway in Human Forearm" @default.
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