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- W2887975610 abstract "The perturbation on the relaxation of solvent water protons induced by the presence of paramagnetic metal-containing systems has been exploited for the design of contrast agents in magnetic resonance imaging applications. Complexes of Gd3+ ions were identified early as the candidates of choice and several, highly stable, Gd-containing contrast agents entered into clinical practice two to three decades ago. Overall, the relationships between the structure and dynamics of paramagnetic metal complexes and the determinants of the proton relaxation enhancement have been well defined. On this basis a number of Gd-containing complexes have been synthetized and tested. Besides the currently used procedures devoted to visualizing tumor perfusion or abnormalities in organ function, Gd-containing contrast agents have found application in quantitative assessments such as DCE-MRI (dynamic contrast enhanced-MRI). At preclinical level, a number of paramagnetic systems have already been proposed as targeting agents of overregulated receptors/transporters or as responsive agents to tissue microenvironment parameters. These studies pave the way to molecular imaging studies with MRI modality." @default.
- W2887975610 created "2018-08-22" @default.
- W2887975610 creator A5015198241 @default.
- W2887975610 creator A5022564566 @default.
- W2887975610 creator A5038724542 @default.
- W2887975610 date "2018-08-07" @default.
- W2887975610 modified "2023-10-16" @default.
- W2887975610 title "Relaxometry and Contrast Agents" @default.
- W2887975610 cites W138860627 @default.
- W2887975610 cites W1492726842 @default.
- W2887975610 cites W152500042 @default.
- W2887975610 cites W1560609297 @default.
- W2887975610 cites W1834479440 @default.
- W2887975610 cites W1909443568 @default.
- W2887975610 cites W1967727706 @default.
- W2887975610 cites W1969137131 @default.
- W2887975610 cites W1971355551 @default.
- W2887975610 cites W1977303945 @default.
- W2887975610 cites W1983497025 @default.
- W2887975610 cites W1983768140 @default.
- W2887975610 cites W1984232298 @default.
- W2887975610 cites W1987036580 @default.
- W2887975610 cites W1988045042 @default.
- W2887975610 cites W1989389526 @default.
- W2887975610 cites W1989436965 @default.
- W2887975610 cites W1990036692 @default.
- W2887975610 cites W1994157091 @default.
- W2887975610 cites W2000001293 @default.
- W2887975610 cites W2005056527 @default.
- W2887975610 cites W2005444217 @default.
- W2887975610 cites W2006324160 @default.
- W2887975610 cites W2008407458 @default.
- W2887975610 cites W2013260644 @default.
- W2887975610 cites W2013441341 @default.
- W2887975610 cites W2017865509 @default.
- W2887975610 cites W2019078240 @default.
- W2887975610 cites W2020492353 @default.
- W2887975610 cites W2025096232 @default.
- W2887975610 cites W2027504763 @default.
- W2887975610 cites W2028377752 @default.
- W2887975610 cites W2028702203 @default.
- W2887975610 cites W2038470532 @default.
- W2887975610 cites W2041712312 @default.
- W2887975610 cites W2047168103 @default.
- W2887975610 cites W2053691477 @default.
- W2887975610 cites W2057185918 @default.
- W2887975610 cites W2059592642 @default.
- W2887975610 cites W2066806630 @default.
- W2887975610 cites W2067101942 @default.
- W2887975610 cites W2072087638 @default.
- W2887975610 cites W2074055233 @default.
- W2887975610 cites W2074858152 @default.
- W2887975610 cites W2080050622 @default.
- W2887975610 cites W2081507521 @default.
- W2887975610 cites W2085014975 @default.
- W2887975610 cites W2086171977 @default.
- W2887975610 cites W2086682697 @default.
- W2887975610 cites W2090476704 @default.
- W2887975610 cites W2098096372 @default.
- W2887975610 cites W2104665849 @default.
- W2887975610 cites W2116696774 @default.
- W2887975610 cites W2117911889 @default.
- W2887975610 cites W2119569899 @default.
- W2887975610 cites W2123905468 @default.
- W2887975610 cites W2124885334 @default.
- W2887975610 cites W2136537672 @default.
- W2887975610 cites W2138002926 @default.
- W2887975610 cites W2140036864 @default.
- W2887975610 cites W2140733566 @default.
- W2887975610 cites W2144383442 @default.
- W2887975610 cites W2160358377 @default.
- W2887975610 cites W2169262628 @default.
- W2887975610 cites W2196985026 @default.
- W2887975610 cites W2268080112 @default.
- W2887975610 cites W2280947722 @default.
- W2887975610 cites W2294900086 @default.
- W2887975610 cites W2322301657 @default.
- W2887975610 cites W2324561117 @default.
- W2887975610 cites W2329419847 @default.
- W2887975610 cites W2409203058 @default.
- W2887975610 cites W2462633331 @default.
- W2887975610 cites W2477920162 @default.
- W2887975610 cites W2483061681 @default.
- W2887975610 cites W2512610702 @default.
- W2887975610 cites W2539845158 @default.
- W2887975610 cites W2556731848 @default.
- W2887975610 cites W2590722565 @default.
- W2887975610 cites W2719220875 @default.
- W2887975610 cites W2743701252 @default.
- W2887975610 cites W2745659425 @default.
- W2887975610 cites W2949889511 @default.
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- W2887975610 doi "https://doi.org/10.1039/9781788013291-00189" @default.
- W2887975610 hasPublicationYear "2018" @default.
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