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- W2887988752 endingPage "2020" @default.
- W2887988752 startingPage "2020" @default.
- W2887988752 abstract "Epidemiological and laboratory studies have shown that green tea and green tea catechins exert beneficial effects on a variety of diseases, including cancer, metabolic syndrome, infectious diseases, and neurodegenerative diseases. In most cases, (−)-epigallocatechin gallate (EGCG) has been shown to play a central role in these effects by green tea. Catechins from other plant sources have also shown health benefits. Many studies have revealed that the binding of EGCG and other catechins to proteins is involved in its action mechanism. Computational docking analysis (CMDA) and X-ray crystallographic analysis (XCA) have provided detailed information on catechin-protein interactions. Several of these studies have revealed that the galloyl moiety anchors it to the cleft of proteins through interactions with its hydroxyl groups, explaining the higher activity of galloylated catechins such as EGCG and epicatechin gallate than non-galloylated catechins. In this paper, we review the results of CMDA and XCA of EGCG and other plant catechins to understand catechin-protein interactions with the expectation of developing new drugs with health-promoting properties." @default.
- W2887988752 created "2018-08-22" @default.
- W2887988752 creator A5016585424 @default.
- W2887988752 creator A5017947153 @default.
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- W2887988752 creator A5068648492 @default.
- W2887988752 creator A5086122848 @default.
- W2887988752 date "2018-08-13" @default.
- W2887988752 modified "2023-10-14" @default.
- W2887988752 title "Computational Molecular Docking and X-ray Crystallographic Studies of Catechins in New Drug Design Strategies" @default.
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