Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887989764> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2887989764 endingPage "244" @default.
- W2887989764 startingPage "237" @default.
- W2887989764 abstract "Mono-ADP-ribosyltransferases of the PARP/ARTD enzyme family are enzymes catalyzing the transfer of a single ADP-ribose unit to target proteins. The enzymes have various roles in vital cellular processes such as DNA repair and transcription, and many of the enzymes are linked to cancer-relevant functions. Thus inhibition of the enzymes is a potential way to discover and develop new drugs against cancer. Here we describe an activity-based screening assay for mono-ADP-ribosyltransferases. The assay utilizes the natural substrate of the enzymes, NAD+, and it is based on chemically converting the leftover substrate to a fluorophore and measuring its relative concentration after the enzymatic reaction. The assay is homogenous, robust, and cost-effective and, most importantly, applicable to mono-ADP-ribosyltransferases as well as poly-ADP-ribosyltransferases for screening of small-molecule inhibitors against the enzymes." @default.
- W2887989764 created "2018-08-22" @default.
- W2887989764 creator A5038563052 @default.
- W2887989764 creator A5057196228 @default.
- W2887989764 creator A5062886298 @default.
- W2887989764 creator A5089344585 @default.
- W2887989764 date "2018-01-01" @default.
- W2887989764 modified "2023-09-23" @default.
- W2887989764 title "Small-Molecule Screening Assay for Mono-ADP-Ribosyltransferases" @default.
- W2887989764 cites W1532086012 @default.
- W2887989764 cites W1975272351 @default.
- W2887989764 cites W2015264243 @default.
- W2887989764 cites W2023015070 @default.
- W2887989764 cites W2058058143 @default.
- W2887989764 cites W2061712281 @default.
- W2887989764 cites W2072493619 @default.
- W2887989764 cites W2072528578 @default.
- W2887989764 cites W2085215116 @default.
- W2887989764 cites W2088689845 @default.
- W2887989764 cites W2141505580 @default.
- W2887989764 cites W2560733654 @default.
- W2887989764 cites W2588135595 @default.
- W2887989764 doi "https://doi.org/10.1007/978-1-4939-8588-3_16" @default.
- W2887989764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30097872" @default.
- W2887989764 hasPublicationYear "2018" @default.
- W2887989764 type Work @default.
- W2887989764 sameAs 2887989764 @default.
- W2887989764 citedByCount "2" @default.
- W2887989764 countsByYear W28879897642021 @default.
- W2887989764 crossrefType "book-chapter" @default.
- W2887989764 hasAuthorship W2887989764A5038563052 @default.
- W2887989764 hasAuthorship W2887989764A5057196228 @default.
- W2887989764 hasAuthorship W2887989764A5062886298 @default.
- W2887989764 hasAuthorship W2887989764A5089344585 @default.
- W2887989764 hasBestOaLocation W28879897642 @default.
- W2887989764 hasConcept C121332964 @default.
- W2887989764 hasConcept C161624437 @default.
- W2887989764 hasConcept C181199279 @default.
- W2887989764 hasConcept C182979987 @default.
- W2887989764 hasConcept C185592680 @default.
- W2887989764 hasConcept C18903297 @default.
- W2887989764 hasConcept C2776376580 @default.
- W2887989764 hasConcept C2777289219 @default.
- W2887989764 hasConcept C2778617687 @default.
- W2887989764 hasConcept C55493867 @default.
- W2887989764 hasConcept C62520636 @default.
- W2887989764 hasConcept C75520062 @default.
- W2887989764 hasConcept C82381507 @default.
- W2887989764 hasConcept C86803240 @default.
- W2887989764 hasConcept C91881484 @default.
- W2887989764 hasConceptScore W2887989764C121332964 @default.
- W2887989764 hasConceptScore W2887989764C161624437 @default.
- W2887989764 hasConceptScore W2887989764C181199279 @default.
- W2887989764 hasConceptScore W2887989764C182979987 @default.
- W2887989764 hasConceptScore W2887989764C185592680 @default.
- W2887989764 hasConceptScore W2887989764C18903297 @default.
- W2887989764 hasConceptScore W2887989764C2776376580 @default.
- W2887989764 hasConceptScore W2887989764C2777289219 @default.
- W2887989764 hasConceptScore W2887989764C2778617687 @default.
- W2887989764 hasConceptScore W2887989764C55493867 @default.
- W2887989764 hasConceptScore W2887989764C62520636 @default.
- W2887989764 hasConceptScore W2887989764C75520062 @default.
- W2887989764 hasConceptScore W2887989764C82381507 @default.
- W2887989764 hasConceptScore W2887989764C86803240 @default.
- W2887989764 hasConceptScore W2887989764C91881484 @default.
- W2887989764 hasLocation W28879897641 @default.
- W2887989764 hasLocation W28879897642 @default.
- W2887989764 hasLocation W28879897643 @default.
- W2887989764 hasOpenAccess W2887989764 @default.
- W2887989764 hasPrimaryLocation W28879897641 @default.
- W2887989764 hasRelatedWork W1790834371 @default.
- W2887989764 hasRelatedWork W1980647462 @default.
- W2887989764 hasRelatedWork W2005799185 @default.
- W2887989764 hasRelatedWork W2016517525 @default.
- W2887989764 hasRelatedWork W2023015070 @default.
- W2887989764 hasRelatedWork W2049887237 @default.
- W2887989764 hasRelatedWork W2074191566 @default.
- W2887989764 hasRelatedWork W2314620439 @default.
- W2887989764 hasRelatedWork W26640823 @default.
- W2887989764 hasRelatedWork W2887989764 @default.
- W2887989764 isParatext "false" @default.
- W2887989764 isRetracted "false" @default.
- W2887989764 magId "2887989764" @default.
- W2887989764 workType "book-chapter" @default.