Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888027727> ?p ?o ?g. }
- W2888027727 abstract "The pervasive role of microRNAs (miRNAs) in cancer pathobiology drives the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, meticulous screening strategies addressing specific tumor targets are needed. Small molecule inhibitors represent an attractive goal for these strategies. In this study, we devised a strategy to screen for small molecule inhibitors that specifically inhibit, directly or indirectly, miR-10b (SMIRs) which is overexpressed in metastatic tumors. We found that the multi-tyrosine kinase inhibitor linifanib could significantly inhibit miR-10b and reverse its oncogenic function in breast cancer and liver cancer both in vitro and in vivo. In addition, we showed that the efficacy of linifanib to inhibit tyrosine kinases was reduced by high miR-10b levels. When the level of miR-10b is high, it can hijack the linifanib and reduce its kinase inhibitory effects in cancer resulting in reduced anti-tumor efficacy. In conclusion, our study describes an effective strategy to screen for small molecule inhibitors of miRNAs. We further propose that miR-10b expression levels, due to the newly described hijacking effect, may be used as a biomarker to select patients for linifanib treatment." @default.
- W2888027727 created "2018-08-31" @default.
- W2888027727 creator A5001850985 @default.
- W2888027727 creator A5013106435 @default.
- W2888027727 creator A5013127324 @default.
- W2888027727 creator A5013673358 @default.
- W2888027727 creator A5013938672 @default.
- W2888027727 creator A5014732857 @default.
- W2888027727 creator A5014839490 @default.
- W2888027727 creator A5024349157 @default.
- W2888027727 creator A5025593348 @default.
- W2888027727 creator A5031866965 @default.
- W2888027727 creator A5033922351 @default.
- W2888027727 creator A5047945025 @default.
- W2888027727 creator A5048425075 @default.
- W2888027727 creator A5062643080 @default.
- W2888027727 creator A5064374408 @default.
- W2888027727 creator A5071074966 @default.
- W2888027727 creator A5072661022 @default.
- W2888027727 creator A5072974743 @default.
- W2888027727 creator A5081595773 @default.
- W2888027727 creator A5082498438 @default.
- W2888027727 creator A5084175905 @default.
- W2888027727 creator A5084281720 @default.
- W2888027727 creator A5088496837 @default.
- W2888027727 creator A5089889412 @default.
- W2888027727 date "2018-08-30" @default.
- W2888027727 modified "2023-10-10" @default.
- W2888027727 title "OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers" @default.
- W2888027727 cites W1520425169 @default.
- W2888027727 cites W1538245709 @default.
- W2888027727 cites W1826315897 @default.
- W2888027727 cites W1971837077 @default.
- W2888027727 cites W1972380031 @default.
- W2888027727 cites W1980804324 @default.
- W2888027727 cites W1992695694 @default.
- W2888027727 cites W1995229013 @default.
- W2888027727 cites W2013842709 @default.
- W2888027727 cites W2015751470 @default.
- W2888027727 cites W2030607381 @default.
- W2888027727 cites W2038349091 @default.
- W2888027727 cites W2047529648 @default.
- W2888027727 cites W2056163405 @default.
- W2888027727 cites W2064131445 @default.
- W2888027727 cites W2079251691 @default.
- W2888027727 cites W2083380754 @default.
- W2888027727 cites W2084415993 @default.
- W2888027727 cites W2087972419 @default.
- W2888027727 cites W2100115701 @default.
- W2888027727 cites W2101174827 @default.
- W2888027727 cites W2106246776 @default.
- W2888027727 cites W2107353587 @default.
- W2888027727 cites W2110789683 @default.
- W2888027727 cites W2120967735 @default.
- W2888027727 cites W2129615821 @default.
- W2888027727 cites W2144753743 @default.
- W2888027727 cites W2154967360 @default.
- W2888027727 cites W2155211141 @default.
- W2888027727 cites W2155411048 @default.
- W2888027727 cites W2160033023 @default.
- W2888027727 cites W2160102037 @default.
- W2888027727 cites W2160899712 @default.
- W2888027727 cites W2163169932 @default.
- W2888027727 cites W2164408432 @default.
- W2888027727 cites W2170957850 @default.
- W2888027727 cites W2171698807 @default.
- W2888027727 cites W2173409576 @default.
- W2888027727 cites W2521569068 @default.
- W2888027727 cites W2598933423 @default.
- W2888027727 cites W4234274504 @default.
- W2888027727 cites W59211302 @default.
- W2888027727 doi "https://doi.org/10.1038/s41598-018-30989-3" @default.
- W2888027727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6117344" @default.
- W2888027727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30166612" @default.
- W2888027727 hasPublicationYear "2018" @default.
- W2888027727 type Work @default.
- W2888027727 sameAs 2888027727 @default.
- W2888027727 citedByCount "20" @default.
- W2888027727 countsByYear W28880277272018 @default.
- W2888027727 countsByYear W28880277272019 @default.
- W2888027727 countsByYear W28880277272020 @default.
- W2888027727 countsByYear W28880277272021 @default.
- W2888027727 countsByYear W28880277272022 @default.
- W2888027727 countsByYear W28880277272023 @default.
- W2888027727 crossrefType "journal-article" @default.
- W2888027727 hasAuthorship W2888027727A5001850985 @default.
- W2888027727 hasAuthorship W2888027727A5013106435 @default.
- W2888027727 hasAuthorship W2888027727A5013127324 @default.
- W2888027727 hasAuthorship W2888027727A5013673358 @default.
- W2888027727 hasAuthorship W2888027727A5013938672 @default.
- W2888027727 hasAuthorship W2888027727A5014732857 @default.
- W2888027727 hasAuthorship W2888027727A5014839490 @default.
- W2888027727 hasAuthorship W2888027727A5024349157 @default.
- W2888027727 hasAuthorship W2888027727A5025593348 @default.
- W2888027727 hasAuthorship W2888027727A5031866965 @default.
- W2888027727 hasAuthorship W2888027727A5033922351 @default.
- W2888027727 hasAuthorship W2888027727A5047945025 @default.
- W2888027727 hasAuthorship W2888027727A5048425075 @default.
- W2888027727 hasAuthorship W2888027727A5062643080 @default.
- W2888027727 hasAuthorship W2888027727A5064374408 @default.