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- W2888028147 abstract "Despite marked clinical successes in the treatment of childhood T-ALL, leukemia relapse, refractory disease and induction failure (around 30% of patients) remain significant clinical problems. New insights in the molecular alterations of ALL have revealed new molecular targets, such as activating mutations of Notch1 (N1), identified in more than 50% of T-ALL patients. However, disruption of N1 signaling by gamma-secretase inhibitors failed to fulfill its clinical promise. Furthermore, little is known about N1 downstream mediators that can be potential therapeutic targets in T-ALL." @default.
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- W2888028147 date "2018-08-01" @default.
- W2888028147 modified "2023-10-14" @default.
- W2888028147 title "Loss of the E3 Ubiquitin Ligase SKP2 Limits De Oncogenic Potential of Notch in T-Cell Lymphoblastic Leukemia" @default.
- W2888028147 doi "https://doi.org/10.1016/j.exphem.2018.06.133" @default.
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