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- W2888064478 abstract "Receptor-interacting protein kinase 1 (RIPK1) is a component of the TNFR1 signaling complex (also known as complex I or TNFR-SC), where its ubiquitylation by cIAP1/2 and LUBAC serves to initiate prosurvival and proinflammatory responses through activation of the MAPK and NF-κB pathways. IKKα/β-mediated phosphorylation of RIPK1 in complex I was shown to maintain RIPK1 in a prosurvival modus. Consequently, conditions affecting proper IKKα/β activation perturb IKKα/β-phosphorylation of RIPK1 and switch the TNF response toward RIPK1 kinase-dependent cell death. Methods to study the posttranslational modifications of RIPK1 in complex I are therefore of great value. Here, we describe a detailed protocol to isolate complex I-associated RIPK1 from cells and provide different tools to study the phosphorylation status of RIPK1 in TNFR1 complex I." @default.
- W2888064478 created "2018-08-31" @default.
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- W2888064478 date "2018-01-01" @default.
- W2888064478 modified "2023-09-23" @default.
- W2888064478 title "Monitoring RIPK1 Phosphorylation in the TNFR1 Signaling Complex" @default.
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- W2888064478 doi "https://doi.org/10.1007/978-1-4939-8754-2_17" @default.
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