FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888066909> ?p ?o ?g. }

• W2888066909 abstract "Alzheimer’s disease (AD) is the most common form of dementia, with no means of cure or prevention. The presence of abnormal disease-related proteins in the population is, in turn, much more common than the incidence of dementia. In this context, the CR hypothesis has been proposed to explain the discontinuity between pathophysiological and clinical expression of AD, suggesting that CR mitigates the effects of pathology on clinical expression and cognition. fMRI studies of the human connectome have recently reported that AD patients present diminished functional efficiency in resting-state networks, leading to a loss in information flow and cognitive processing. No study has investigated, however, whether CR modifies the effects of the pathology in functional network efficiency in AD patients. We analyzed the relationship between CR, pathophysiology and network efficiency, and whether CR modifies the relationship between them. Fourteen mild AD, 28 amnestic mild cognitive impairment due to AD (aMCI), and 28 controls were enrolled. We used education to measure CR, CSF biomarkers to evaluate pathophysiology, and graph metrics to measure network efficiency. We found no relationship between CR and CSF biomarkers; CR was related to higher network efficiency in all groups; and abnormal levels of CSF protein biomarkers were related to more efficient networks in the AD group. Education modified the effects of tau-related pathology in the aMCI and mild AD groups. Although higher CR might not protect individuals from developing AD pathophysiology, AD patients with higher CR are better able to cope with the effects of pathology – presenting more efficient networks despite pathology burden. The present study highlights that interventions focusing on cognitive stimulation might be useful to slow age-related cognitive decline or dementia and lengthen healthy ageing." @default.
• W2888066909 created "2018-08-31" @default.
• W2888066909 creator A5012284122 @default.
• W2888066909 creator A5017489689 @default.
• W2888066909 creator A5017944863 @default.
• W2888066909 creator A5026563901 @default.
• W2888066909 creator A5032166924 @default.
• W2888066909 creator A5032217448 @default.
• W2888066909 creator A5036022119 @default.
• W2888066909 creator A5046924742 @default.
• W2888066909 creator A5048852250 @default.
• W2888066909 creator A5052333709 @default.
• W2888066909 creator A5054270022 @default.
• W2888066909 creator A5088118831 @default.
• W2888066909 date "2018-08-21" @default.
• W2888066909 modified "2023-10-17" @default.
• W2888066909 title "Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer’s Disease" @default.
• W2888066909 cites W1486416255 @default.
• W2888066909 cites W1497201830 @default.
• W2888066909 cites W1532163249 @default.
• W2888066909 cites W1584715608 @default.
• W2888066909 cites W1650372104 @default.
• W2888066909 cites W1662469265 @default.
• W2888066909 cites W1808010172 @default.
• W2888066909 cites W1825977234 @default.
• W2888066909 cites W1913608598 @default.
• W2888066909 cites W1943229661 @default.
• W2888066909 cites W1957710718 @default.
• W2888066909 cites W1970428104 @default.
• W2888066909 cites W1972009531 @default.
• W2888066909 cites W1976968567 @default.
• W2888066909 cites W1977125590 @default.
• W2888066909 cites W1985871002 @default.
• W2888066909 cites W1991952617 @default.
• W2888066909 cites W1993134224 @default.
• W2888066909 cites W1995785495 @default.
• W2888066909 cites W1996496731 @default.
• W2888066909 cites W1996657043 @default.
• W2888066909 cites W1997074193 @default.
• W2888066909 cites W1997186465 @default.
• W2888066909 cites W1999653836 @default.
• W2888066909 cites W2000363330 @default.
• W2888066909 cites W2002222426 @default.
• W2888066909 cites W2009821801 @default.
• W2888066909 cites W2011541551 @default.
• W2888066909 cites W2014897304 @default.
• W2888066909 cites W2021590775 @default.
• W2888066909 cites W2047840225 @default.
• W2888066909 cites W2052978590 @default.
• W2888066909 cites W2059143861 @default.
• W2888066909 cites W2061216396 @default.
• W2888066909 cites W2062825859 @default.
• W2888066909 cites W2064694967 @default.
• W2888066909 cites W2068252829 @default.
• W2888066909 cites W2071700556 @default.
• W2888066909 cites W2073659698 @default.
• W2888066909 cites W2075193321 @default.
• W2888066909 cites W2077067735 @default.
• W2888066909 cites W2079225922 @default.
• W2888066909 cites W2079493264 @default.
• W2888066909 cites W2081093524 @default.
• W2888066909 cites W2083194463 @default.
• W2888066909 cites W2085738367 @default.
• W2888066909 cites W2085870059 @default.
• W2888066909 cites W2088540084 @default.
• W2888066909 cites W2091931051 @default.
• W2888066909 cites W2092276546 @default.
• W2888066909 cites W2095245818 @default.
• W2888066909 cites W2096192426 @default.
• W2888066909 cites W2101219946 @default.
• W2888066909 cites W2103860290 @default.
• W2888066909 cites W2107202876 @default.
• W2888066909 cites W2112710468 @default.
• W2888066909 cites W2115017507 @default.
• W2888066909 cites W2118323338 @default.
• W2888066909 cites W2119997337 @default.
• W2888066909 cites W2122042734 @default.
• W2888066909 cites W2126838454 @default.
• W2888066909 cites W2132670259 @default.
• W2888066909 cites W2134613265 @default.
• W2888066909 cites W2135771073 @default.
• W2888066909 cites W2136395604 @default.
• W2888066909 cites W2138991775 @default.
• W2888066909 cites W2144907160 @default.
• W2888066909 cites W2145173243 @default.
• W2888066909 cites W2155575770 @default.
• W2888066909 cites W2160715919 @default.
• W2888066909 cites W2165985389 @default.
• W2888066909 cites W2167840686 @default.
• W2888066909 cites W2185245119 @default.
• W2888066909 cites W2210854791 @default.
• W2888066909 cites W2262326631 @default.
• W2888066909 cites W2346544424 @default.
• W2888066909 cites W2435914733 @default.
• W2888066909 cites W2473821704 @default.
• W2888066909 cites W2512344001 @default.
• W2888066909 cites W2522721205 @default.
• W2888066909 cites W2530303434 @default.
• W2888066909 cites W2557843044 @default.
• W2888066909 cites W2559926263 @default.

• next