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- W2888082172 abstract "Although downregulation of DICER - a critical enzyme in microRNA (miRNA) maturation - reportedly promotes cancer metastasis, understanding of its upstream regulators remains limited. Our recent study demonstrated a noncanonical oncogenic effect of hypoxia-inducible factor-1α (HIF-1α), which directly binds with DICER to promote PARKIN-mediated autophagic-lysosomal proteolysis and consequently suppresses miRNA biogenesis, facilitating metastasis." @default.
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- W2888082172 date "2018-08-24" @default.
- W2888082172 modified "2023-10-17" @default.
- W2888082172 title "Dual mechanism of DICER downregulation facilitates cancer metastasis" @default.
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- W2888082172 doi "https://doi.org/10.1080/23723556.2018.1472056" @default.
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