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- W2888090354 abstract "During development, multipotent retinal progenitor cells generate a large number of unique cell types. Recent evidence suggests that there are fate-restricted progenitor cell states in addition to multipotent ones. Here we report a transcriptomic analysis of fate- restricted progenitor cells biased to produce cone photoreceptors and horizontal cells, marked by the THRB cis-regulatory element ThrbCRM1. Comparison to a control population enriched in multipotent progenitor cells identified several genes considered to be pan-progenitor, such as VSX2, LHX2, and PAX6, as downregulated in these fate- restricted retinal progenitor cells. This differential regulation occurs in chick and in a different restricted progenitor population in mouse suggesting that this is a conserved feature of progenitor dynamics during retinal development. S-phase labeling also revealed that nuclear positions of restricted progenitor populations occupy distinct spatial niches within the developing chick retina. Using a conserved regulatory element proximal to the VSX2 gene, a potential negative feedback mechanism from specific transcription factors enriched in cone/horizontal cell progenitor cells was identified. This study identifies conserved molecular and cellular changes that occur during the generation of fate restricted retinal progenitor cells from multipotent retinal progenitor cells." @default.
- W2888090354 created "2018-08-31" @default.
- W2888090354 creator A5039646451 @default.
- W2888090354 creator A5074519091 @default.
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- W2888090354 date "2018-11-01" @default.
- W2888090354 modified "2023-10-16" @default.
- W2888090354 title "Fate-restricted retinal progenitor cells adopt a molecular profile and spatial position distinct from multipotent progenitor cells" @default.
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- W2888090354 doi "https://doi.org/10.1016/j.ydbio.2018.06.023" @default.
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