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• W2888092783 abstract "To demonstrate efficient aerosol delivery through an in vitro nasal model using a dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied during low-flow nasal cannula (LFNC) therapy. A previously developed LV-DPI was connected to a LFNC system with 4 mm diameter tubing. System connections and the nasal cannula interface were replaced with streamlined components. To simulate nasal respiration, an in vitro nasal model was connected to a downstream lung simulator that produced either passive or deep nasal respiration. Performance of a commercial mesh nebulizer system was also considered. For the optimized system, steady state cannula emitted dose was 75% of the capsule loaded dose. With cyclic nasal breathing, delivery efficiency to the tracheal filter was 53–55% of the loaded dose, which was just under the design target of 60%. Compared with a commercially available mesh nebulizer, the optimal LV-DPI was 40-fold more efficient and 150 times faster in terms of delivering aerosol to the lungs. The optimized LV-DPI system is capable of high efficiency lung delivery of powder aerosols through a challenging nasal cannula interface." @default.
• W2888092783 created "2018-08-31" @default.
• W2888092783 creator A5001437430 @default.
• W2888092783 creator A5026680167 @default.
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• W2888092783 date "2018-08-21" @default.
• W2888092783 modified "2023-10-16" @default.
• W2888092783 title "Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume" @default.
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• W2888092783 doi "https://doi.org/10.1007/s11095-018-2473-7" @default.
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• W2888092783 hasPublicationYear "2018" @default.
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