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- W2888130521 abstract "Pre-clinical data and human trials indicate that resveratrol supplementation may help to counteract diabetes. Several mechanisms of action have been proposed to explain its metabolic benefits, including activation of sirtuins and estrogen receptors (ER) to promote glucose transporter type-4 (GLUT4) translocation and increase glucose uptake. Resveratrol can also enhance vasodilator function, yet the possibility that this action might help to alleviate insulin resistance in type-2 diabetes mellitus has received little attention. In this brief review we propose that, by restoring impaired endothelium-dependent vasodilatation in insulin resistant individuals resveratrol increases blood perfusion of skeletal muscle, thereby facilitating glucose delivery and utilization with resultant improvement of insulin sensitivity. Thus, circulatory improvements by vasoactive nutrients such as resveratrol may play a role in preventing or alleviating insulin resistance." @default.
- W2888130521 created "2018-08-31" @default.
- W2888130521 creator A5041176335 @default.
- W2888130521 creator A5060996575 @default.
- W2888130521 date "2018-08-24" @default.
- W2888130521 modified "2023-09-26" @default.
- W2888130521 title "Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation" @default.
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- W2888130521 doi "https://doi.org/10.3390/nu10091160" @default.
- W2888130521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6165300" @default.
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- W2888130521 hasPublicationYear "2018" @default.
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