Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888133089> ?p ?o ?g. }
- W2888133089 endingPage "2898" @default.
- W2888133089 startingPage "2892" @default.
- W2888133089 abstract "Based on the exceptionally high stability of γPNA duplexes, we designed a peptide/γPNA chimera in which a cell-penetrating TAT peptide is flanked by two short complementary γPNA segments. Intramolecular hybridization of the γPNA segments results in a stable hairpin conformation in which the TAT peptide is constrained to form the loop. The TAT/γPNA hairpin (self-cyclized TAT peptide) enters cells at least 10-fold more efficiently than its nonhairpin analog in which the two γPNA segments are noncomplementary. Extending one of the γPNA segments in the hairpin results in an overhang that can be used for binding and delivering a variety of nucleic acid-conjugated molecules into cells via hybridization to the overhang. We demonstrated efficient cellular delivery of a protein (as low as 10 nM) and a DNA tetrahedron by a TAT/γPNA hairpin." @default.
- W2888133089 created "2018-08-31" @default.
- W2888133089 creator A5028325980 @default.
- W2888133089 creator A5038997100 @default.
- W2888133089 creator A5077573766 @default.
- W2888133089 date "2018-08-21" @default.
- W2888133089 modified "2023-10-13" @default.
- W2888133089 title "Closing the Loop: Constraining TAT Peptide by γPNA Hairpin for Enhanced Cellular Delivery of Biomolecules" @default.
- W2888133089 cites W1561759065 @default.
- W2888133089 cites W1973528774 @default.
- W2888133089 cites W1975451609 @default.
- W2888133089 cites W1978940302 @default.
- W2888133089 cites W1996712727 @default.
- W2888133089 cites W1998269261 @default.
- W2888133089 cites W2000625273 @default.
- W2888133089 cites W2001582257 @default.
- W2888133089 cites W2001925917 @default.
- W2888133089 cites W2004604806 @default.
- W2888133089 cites W2005835630 @default.
- W2888133089 cites W2010659535 @default.
- W2888133089 cites W2019818589 @default.
- W2888133089 cites W2021307619 @default.
- W2888133089 cites W2024949907 @default.
- W2888133089 cites W2026710381 @default.
- W2888133089 cites W2032129221 @default.
- W2888133089 cites W2032846952 @default.
- W2888133089 cites W2040054282 @default.
- W2888133089 cites W2041593863 @default.
- W2888133089 cites W2042143995 @default.
- W2888133089 cites W2047879084 @default.
- W2888133089 cites W2049307465 @default.
- W2888133089 cites W2070693578 @default.
- W2888133089 cites W2072895616 @default.
- W2888133089 cites W2080356101 @default.
- W2888133089 cites W2085523918 @default.
- W2888133089 cites W2103290350 @default.
- W2888133089 cites W2103609218 @default.
- W2888133089 cites W2105668301 @default.
- W2888133089 cites W2109741979 @default.
- W2888133089 cites W2144596898 @default.
- W2888133089 cites W2151366879 @default.
- W2888133089 cites W2157327967 @default.
- W2888133089 cites W2160902183 @default.
- W2888133089 cites W2286654631 @default.
- W2888133089 cites W2323616931 @default.
- W2888133089 cites W2325296459 @default.
- W2888133089 cites W2405667465 @default.
- W2888133089 cites W2415738872 @default.
- W2888133089 cites W2473622490 @default.
- W2888133089 cites W2612422703 @default.
- W2888133089 cites W2773223888 @default.
- W2888133089 cites W2807670244 @default.
- W2888133089 doi "https://doi.org/10.1021/acs.bioconjchem.8b00495" @default.
- W2888133089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30130094" @default.
- W2888133089 hasPublicationYear "2018" @default.
- W2888133089 type Work @default.
- W2888133089 sameAs 2888133089 @default.
- W2888133089 citedByCount "18" @default.
- W2888133089 countsByYear W28881330892019 @default.
- W2888133089 countsByYear W28881330892020 @default.
- W2888133089 countsByYear W28881330892021 @default.
- W2888133089 countsByYear W28881330892022 @default.
- W2888133089 countsByYear W28881330892023 @default.
- W2888133089 crossrefType "journal-article" @default.
- W2888133089 hasAuthorship W2888133089A5028325980 @default.
- W2888133089 hasAuthorship W2888133089A5038997100 @default.
- W2888133089 hasAuthorship W2888133089A5077573766 @default.
- W2888133089 hasConcept C104317684 @default.
- W2888133089 hasConcept C112613896 @default.
- W2888133089 hasConcept C12554922 @default.
- W2888133089 hasConcept C178790620 @default.
- W2888133089 hasConcept C185592680 @default.
- W2888133089 hasConcept C190232843 @default.
- W2888133089 hasConcept C24107716 @default.
- W2888133089 hasConcept C2777343594 @default.
- W2888133089 hasConcept C2779281246 @default.
- W2888133089 hasConcept C521977710 @default.
- W2888133089 hasConcept C552990157 @default.
- W2888133089 hasConcept C55493867 @default.
- W2888133089 hasConcept C67705224 @default.
- W2888133089 hasConcept C86803240 @default.
- W2888133089 hasConceptScore W2888133089C104317684 @default.
- W2888133089 hasConceptScore W2888133089C112613896 @default.
- W2888133089 hasConceptScore W2888133089C12554922 @default.
- W2888133089 hasConceptScore W2888133089C178790620 @default.
- W2888133089 hasConceptScore W2888133089C185592680 @default.
- W2888133089 hasConceptScore W2888133089C190232843 @default.
- W2888133089 hasConceptScore W2888133089C24107716 @default.
- W2888133089 hasConceptScore W2888133089C2777343594 @default.
- W2888133089 hasConceptScore W2888133089C2779281246 @default.
- W2888133089 hasConceptScore W2888133089C521977710 @default.
- W2888133089 hasConceptScore W2888133089C552990157 @default.
- W2888133089 hasConceptScore W2888133089C55493867 @default.
- W2888133089 hasConceptScore W2888133089C67705224 @default.
- W2888133089 hasConceptScore W2888133089C86803240 @default.
- W2888133089 hasFunder F4320306316 @default.
- W2888133089 hasIssue "9" @default.
- W2888133089 hasLocation W28881330891 @default.