FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888272762> ?p ?o ?g. }

• W2888272762 abstract "Enterotoxigenic Escherichia coli (ETEC) is a global diarrheal pathogen that utilizes adhesins and secreted enterotoxins to cause disease in mammalian hosts. Decades of research on virulence factor regulation in ETEC has revealed a variety of environmental factors that influence gene expression, including bile, pH, bicarbonate, osmolarity, and glucose. However, other hallmarks of the intestinal tract, such as low oxygen availability, have not been examined. Further, determining how ETEC integrates these signals in the complex host environment is challenging. To address this, we characterized ETEC’s response to the human host using samples from a controlled human infection model. We found ETEC senses environmental oxygen to globally influence virulence factor expression via the oxygen-sensitive transcriptional regulator fumarate and nitrate reduction (FNR) regulator. In vitro anaerobic growth replicates the in vivo virulence factor expression profile, and deletion of fnr in ETEC strain H10407 results in a significant increase in expression of all classical virulence factors, including the colonization factor antigen I (CFA/I) adhesin operon and both heat-stable and heat-labile enterotoxins. These data depict a model of ETEC infection where FNR activity can globally influence virulence gene expression, and therefore proximity to the oxygenated zone bordering intestinal epithelial cells likely influences ETEC virulence gene expression in vivo. Outside of the host, ETEC biofilms are associated with seasonal ETEC epidemics, and we find FNR is a regulator of biofilm production. Together these data suggest FNR-dependent oxygen sensing in ETEC has implications for human infection inside and outside of the host." @default.
• W2888272762 created "2018-08-31" @default.
• W2888272762 creator A5005242730 @default.
• W2888272762 creator A5010030154 @default.
• W2888272762 creator A5012155779 @default.
• W2888272762 creator A5013238695 @default.
• W2888272762 creator A5017793381 @default.
• W2888272762 creator A5031561945 @default.
• W2888272762 creator A5033069223 @default.
• W2888272762 creator A5040382258 @default.
• W2888272762 creator A5043080193 @default.
• W2888272762 creator A5044987281 @default.
• W2888272762 creator A5061419619 @default.
• W2888272762 creator A5063690624 @default.
• W2888272762 creator A5070514995 @default.
• W2888272762 creator A5073031989 @default.
• W2888272762 creator A5075861647 @default.
• W2888272762 creator A5082723460 @default.
• W2888272762 creator A5087818802 @default.
• W2888272762 date "2018-08-20" @default.
• W2888272762 modified "2023-10-18" @default.
• W2888272762 title "Enterotoxigenic <i>E. coli</i> virulence gene regulation in human infections" @default.
• W2888272762 cites W1483396672 @default.
• W2888272762 cites W1525738630 @default.
• W2888272762 cites W1769141315 @default.
• W2888272762 cites W1970896993 @default.
• W2888272762 cites W1971602185 @default.
• W2888272762 cites W1975677298 @default.
• W2888272762 cites W1984882823 @default.
• W2888272762 cites W1989938301 @default.
• W2888272762 cites W1990904807 @default.
• W2888272762 cites W1991251012 @default.
• W2888272762 cites W1997882630 @default.
• W2888272762 cites W1998311599 @default.
• W2888272762 cites W2014651106 @default.
• W2888272762 cites W2015794971 @default.
• W2888272762 cites W2023683042 @default.
• W2888272762 cites W2027271580 @default.
• W2888272762 cites W2037383561 @default.
• W2888272762 cites W2055083940 @default.
• W2888272762 cites W2055976044 @default.
• W2888272762 cites W2066000033 @default.
• W2888272762 cites W2083275944 @default.
• W2888272762 cites W2094223414 @default.
• W2888272762 cites W2103318802 @default.
• W2888272762 cites W2108768412 @default.
• W2888272762 cites W2108976360 @default.
• W2888272762 cites W2116137883 @default.
• W2888272762 cites W2117054757 @default.
• W2888272762 cites W2122679795 @default.
• W2888272762 cites W2127369887 @default.
• W2888272762 cites W2134042260 @default.
• W2888272762 cites W2140861523 @default.
• W2888272762 cites W2144305638 @default.
• W2888272762 cites W2147893409 @default.
• W2888272762 cites W2171373448 @default.
• W2888272762 cites W2177790778 @default.
• W2888272762 cites W2189489982 @default.
• W2888272762 cites W2217024838 @default.
• W2888272762 cites W2335715324 @default.
• W2888272762 cites W2480010979 @default.
• W2888272762 cites W2521212801 @default.
• W2888272762 cites W2604097653 @default.
• W2888272762 cites W2612460231 @default.
• W2888272762 cites W2618347416 @default.
• W2888272762 cites W2673701640 @default.
• W2888272762 cites W2741314987 @default.
• W2888272762 cites W2760173088 @default.
• W2888272762 cites W2762580239 @default.
• W2888272762 cites W2767229406 @default.
• W2888272762 cites W2788050391 @default.
• W2888272762 cites W2795318775 @default.
• W2888272762 cites W2795852373 @default.
• W2888272762 doi "https://doi.org/10.1073/pnas.1808982115" @default.
• W2888272762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156659" @default.
• W2888272762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30126994" @default.
• W2888272762 hasPublicationYear "2018" @default.
• W2888272762 type Work @default.
• W2888272762 sameAs 2888272762 @default.
• W2888272762 citedByCount "49" @default.
• W2888272762 countsByYear W28882727622018 @default.
• W2888272762 countsByYear W28882727622019 @default.
• W2888272762 countsByYear W28882727622020 @default.
• W2888272762 countsByYear W28882727622021 @default.
• W2888272762 countsByYear W28882727622022 @default.
• W2888272762 countsByYear W28882727622023 @default.
• W2888272762 crossrefType "journal-article" @default.
• W2888272762 hasAuthorship W2888272762A5005242730 @default.
• W2888272762 hasAuthorship W2888272762A5010030154 @default.
• W2888272762 hasAuthorship W2888272762A5012155779 @default.
• W2888272762 hasAuthorship W2888272762A5013238695 @default.
• W2888272762 hasAuthorship W2888272762A5017793381 @default.
• W2888272762 hasAuthorship W2888272762A5031561945 @default.
• W2888272762 hasAuthorship W2888272762A5033069223 @default.
• W2888272762 hasAuthorship W2888272762A5040382258 @default.
• W2888272762 hasAuthorship W2888272762A5043080193 @default.
• W2888272762 hasAuthorship W2888272762A5044987281 @default.
• W2888272762 hasAuthorship W2888272762A5061419619 @default.
• W2888272762 hasAuthorship W2888272762A5063690624 @default.
• W2888272762 hasAuthorship W2888272762A5070514995 @default.

• next