FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888287029> ?p ?o ?g. }

• W2888287029 endingPage "868" @default.
• W2888287029 startingPage "855" @default.
• W2888287029 abstract "miR160 adjusts auxin-mediated development by post-transcriptional regulation of the auxin response factors ARF10/16/17. In tomato, knockdown of miR160 (sly-miR160) suggested that it is required for auxin-driven leaf blade outgrowth, but whether additional developmental events are adjusted by sly-miR160 is not clear. Here, the SlMIR160 genes and the genes of its SlARFs targets were edited by CRISPR/Cas9 resulting in the isolation of loss-of-function mutants. In addition, hypomorphic mutants that accumulate variable reduced levels of sly-miR160a were isolated. We found that the loss-of-function mutants in SlMIR160a (CR-slmir160a-6/7) produced only four wiry leaves, whereas the hypomorphic mutants developed leaves and flowers with graded developmental abnormalities. Phenotypic severity correlated with the upregulation of SlARF10A. Consistent with that, double mutants in SlMIR160a and SlARF10A restored leaf and flower development indicating that over-accumulation of SlARF10A underlay the developmental abnormalities exhibited in the CR-slmir160a mutants. Phenotype severity also correlated with the upregulation of the SHOOT MERISTEMLESS homolog Tomato Knotted 2, which in turn activated the transcription of the cytokinin biosynthesis genes SlIPT2 and SlIPT4. However, no change in Tomato Knotted 2 was detected in the absence of SlARF10A, suggesting that it is upregulated due to auxin signaling suppression by SlARF10A. Knockout of sly-miR160a-targeted SlARFs showed that whereas SlARF10A is indispensable for leaf blade outgrowth and floral organ patterning, the functions of SlARF16A and SlARF17 are redundant. Taken together our results suggest that sly-miR160a promotes blade outgrowth as well as leaf and leaflet initiation and floral organ development through the quantitative regulation of its major target SlARF10A." @default.
• W2888287029 created "2018-08-31" @default.
• W2888287029 creator A5035945225 @default.
• W2888287029 creator A5041423131 @default.
• W2888287029 creator A5054220059 @default.
• W2888287029 creator A5057395575 @default.
• W2888287029 date "2018-10-08" @default.
• W2888287029 modified "2023-10-17" @default.
• W2888287029 title "Tuning of <i>SlARF10A</i> dosage by sly-miR160a is critical for auxin-mediated compound leaf and flower development" @default.
• W2888287029 cites W1589807584 @default.
• W2888287029 cites W1900047315 @default.
• W2888287029 cites W1964552017 @default.
• W2888287029 cites W1967543716 @default.
• W2888287029 cites W1974833625 @default.
• W2888287029 cites W1978125499 @default.
• W2888287029 cites W1982321194 @default.
• W2888287029 cites W1989885004 @default.
• W2888287029 cites W1996025323 @default.
• W2888287029 cites W2005124332 @default.
• W2888287029 cites W2005154874 @default.
• W2888287029 cites W2014297764 @default.
• W2888287029 cites W2014892526 @default.
• W2888287029 cites W2018322506 @default.
• W2888287029 cites W2019285305 @default.
• W2888287029 cites W2021767455 @default.
• W2888287029 cites W2038146075 @default.
• W2888287029 cites W2041886340 @default.
• W2888287029 cites W2046720489 @default.
• W2888287029 cites W2053915285 @default.
• W2888287029 cites W2056470759 @default.
• W2888287029 cites W2064949291 @default.
• W2888287029 cites W2071697833 @default.
• W2888287029 cites W2090230257 @default.
• W2888287029 cites W2096600985 @default.
• W2888287029 cites W2098270582 @default.
• W2888287029 cites W2109820805 @default.
• W2888287029 cites W2111250074 @default.
• W2888287029 cites W2113157846 @default.
• W2888287029 cites W2119022968 @default.
• W2888287029 cites W2119673666 @default.
• W2888287029 cites W2127577514 @default.
• W2888287029 cites W2132334048 @default.
• W2888287029 cites W2138238880 @default.
• W2888287029 cites W2138340439 @default.
• W2888287029 cites W2139468021 @default.
• W2888287029 cites W2139582953 @default.
• W2888287029 cites W2140798588 @default.
• W2888287029 cites W2143310096 @default.
• W2888287029 cites W2149685146 @default.
• W2888287029 cites W2150415116 @default.
• W2888287029 cites W2152002853 @default.
• W2888287029 cites W2153606005 @default.
• W2888287029 cites W2155906714 @default.
• W2888287029 cites W2156413023 @default.
• W2888287029 cites W2156852055 @default.
• W2888287029 cites W2161337189 @default.
• W2888287029 cites W2168911096 @default.
• W2888287029 cites W2170163334 @default.
• W2888287029 cites W2296903196 @default.
• W2888287029 cites W2344911102 @default.
• W2888287029 cites W2404647112 @default.
• W2888287029 cites W2547442264 @default.
• W2888287029 cites W2740790229 @default.
• W2888287029 cites W2777682755 @default.
• W2888287029 doi "https://doi.org/10.1111/tpj.14073" @default.
• W2888287029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30144341" @default.
• W2888287029 hasPublicationYear "2018" @default.
• W2888287029 type Work @default.
• W2888287029 sameAs 2888287029 @default.
• W2888287029 citedByCount "43" @default.
• W2888287029 countsByYear W28882870292019 @default.
• W2888287029 countsByYear W28882870292020 @default.
• W2888287029 countsByYear W28882870292021 @default.
• W2888287029 countsByYear W28882870292022 @default.
• W2888287029 countsByYear W28882870292023 @default.
• W2888287029 crossrefType "journal-article" @default.
• W2888287029 hasAuthorship W2888287029A5035945225 @default.
• W2888287029 hasAuthorship W2888287029A5041423131 @default.
• W2888287029 hasAuthorship W2888287029A5054220059 @default.
• W2888287029 hasAuthorship W2888287029A5057395575 @default.
• W2888287029 hasBestOaLocation W28882870291 @default.
• W2888287029 hasConcept C104317684 @default.
• W2888287029 hasConcept C127561419 @default.
• W2888287029 hasConcept C127716648 @default.
• W2888287029 hasConcept C143065580 @default.
• W2888287029 hasConcept C150194340 @default.
• W2888287029 hasConcept C162317418 @default.
• W2888287029 hasConcept C173396325 @default.
• W2888287029 hasConcept C207778908 @default.
• W2888287029 hasConcept C2780369116 @default.
• W2888287029 hasConcept C54355233 @default.
• W2888287029 hasConcept C59822182 @default.
• W2888287029 hasConcept C86339819 @default.
• W2888287029 hasConcept C86803240 @default.
• W2888287029 hasConcept C95444343 @default.
• W2888287029 hasConceptScore W2888287029C104317684 @default.
• W2888287029 hasConceptScore W2888287029C127561419 @default.
• W2888287029 hasConceptScore W2888287029C127716648 @default.

• next