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- W2888287252 abstract "pH-sensing ovarian cancer G-protein coupled receptor-1 [OGR1/GPR68] is regulated by key inflammatory cytokines. Patients suffering from inflammatory bowel diseases [IBDs] express increased mucosal levels of OGR1 compared with non-IBD controls. pH-sensing may be relevant for progression of fibrosis, as extracellular acidification leads to fibroblast activation and extracellular matrix remodelling. We aimed to determine OGR1 expression in fibrotic lesions in the intestine of Crohn's disease [CD] patients, and the effect of Ogr1 deficiency in fibrogenesis.Human fibrotic and non-fibrotic terminal ileum was obtained from CD patients undergoing ileocaecal resection due to stenosis. Gene expression of fibrosis markers and pH-sensing receptors was analysed. For the initiation of fibrosis in vivo, spontaneous colitis by Il10-/-, dextran sodium sulfate [DSS]-induced chronic colitis and the heterotopic intestinal transplantation model were used.Increased expression of fibrosis markers was accompanied by an increase in OGR1 [2.71 ± 0.69 vs 1.18 ± 0.03, p = 0.016] in fibrosis-affected human terminal ileum, compared with the non-fibrotic resection margin. Positive correlation between OGR1 expression and pro-fibrotic cytokines [TGFB1 and CTGF] and pro-collagens was observed. The heterotopic animal model for intestinal fibrosis transplanted with terminal ileum from Ogr1-/- mice showed a decrease in mRNA expression of fibrosis markers as well as a decrease in collagen layer thickness and hydroxyproline compared with grafts from wild-type mice.OGR1 expression was correlated with increased expression levels of pro-fibrotic genes and collagen deposition. Ogr1 deficiency was associated with a decrease in fibrosis formation. Targeting OGR1 may be a potential new treatment option for IBD-associated fibrosis." @default.
- W2888287252 created "2018-08-31" @default.
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- W2888287252 date "2018-08-25" @default.
- W2888287252 modified "2023-10-05" @default.
- W2888287252 title "Intestinal Activation of pH-Sensing Receptor OGR1 [GPR68] Contributes to Fibrogenesis" @default.
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- W2888287252 cites W1973397356 @default.
- W2888287252 cites W1981461721 @default.
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- W2888287252 cites W1984438195 @default.
- W2888287252 cites W1987778106 @default.
- W2888287252 cites W1989738331 @default.
- W2888287252 cites W1991189920 @default.
- W2888287252 cites W1996406504 @default.
- W2888287252 cites W2013396535 @default.
- W2888287252 cites W2016553429 @default.
- W2888287252 cites W2019851250 @default.
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- W2888287252 cites W2045402066 @default.
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- W2888287252 cites W2086514236 @default.
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- W2888287252 doi "https://doi.org/10.1093/ecco-jcc/jjy118" @default.
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