FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888290100> ?p ?o ?g. }

• W2888290100 endingPage "424" @default.
• W2888290100 startingPage "414" @default.
• W2888290100 abstract "Malaria-infected individuals often harbor mixtures of genetically distinct parasite genotypes. We studied intra-host dynamics of parasite genotypes co-infecting asymptomatic adults in an area of intense malaria transmission in Chikhwawa, Malawi. Serial blood samples (5 ml) were collected over seven consecutive days from 25 adults with asymptomatic Plasmodium falciparum malaria and analyzed to determine whether a single peripheral blood sample accurately captures within-host parasite diversity. Blood samples from three of the participants were also analyzed by limiting dilution cloning and SNP genotyping of the parasite clones isolated to examine both the number and relatedness of co-infecting parasite haplotypes. We observed rapid turnover of co-infecting parasite genotypes in 88% of the individuals sampled (n = 22) such that the genetic composition of parasites infecting these individuals changed dramatically over the course of seven days of follow up. Nineteen of the 25 individuals sampled (76%) carried multiple parasite genotypes at baseline. Analysis of serial blood samples from three of the individuals revealed that they harbored 6, 12 and 17 distinct parasite haplotypes respectively. Approximately 70% of parasite haplotypes recovered from the three extensively sampled individuals were unrelated (proportion of shared alleles <83.3%) and were deemed to have primarily arisen from superinfection (inoculation of unrelated parasite haplotypes through multiple mosquito bites). The rest were related at the half-sib level or greater and were deemed to have been inoculated into individual human hosts via parasite co-transmission from single mosquito bites. These findings add further to the growing weight of evidence indicating that a single blood sample poorly captures within-host parasite diversity and underscore the importance of repeated blood sampling to accurately capture within-host parasite ecology. Our data also demonstrate a more pronounced role for parasite co-transmission in generating within-host parasite diversity in high transmission settings than previously assumed. Taken together, these findings have important implications for understanding the evolution of drug resistance, malaria transmission, parasite virulence, allocation of gametocyte sex ratios and acquisition of malaria immunity." @default.
• W2888290100 created "2018-08-31" @default.
• W2888290100 creator A5008177587 @default.
• W2888290100 creator A5021621374 @default.
• W2888290100 creator A5032482887 @default.
• W2888290100 creator A5061182167 @default.
• W2888290100 creator A5065971487 @default.
• W2888290100 date "2018-11-01" @default.
• W2888290100 modified "2023-09-27" @default.
• W2888290100 title "Intra-host dynamics of co-infecting parasite genotypes in asymptomatic malaria patients" @default.
• W2888290100 cites W1504597425 @default.
• W2888290100 cites W1606736507 @default.
• W2888290100 cites W1879747857 @default.
• W2888290100 cites W1966459680 @default.
• W2888290100 cites W1966834016 @default.
• W2888290100 cites W1972014763 @default.
• W2888290100 cites W1977845940 @default.
• W2888290100 cites W1992482886 @default.
• W2888290100 cites W1993741644 @default.
• W2888290100 cites W1997493309 @default.
• W2888290100 cites W2001168626 @default.
• W2888290100 cites W2003124479 @default.
• W2888290100 cites W2005653430 @default.
• W2888290100 cites W2006352451 @default.
• W2888290100 cites W2010154952 @default.
• W2888290100 cites W2015417822 @default.
• W2888290100 cites W2016485007 @default.
• W2888290100 cites W2016828296 @default.
• W2888290100 cites W2019851585 @default.
• W2888290100 cites W2024539339 @default.
• W2888290100 cites W2025363484 @default.
• W2888290100 cites W2028126135 @default.
• W2888290100 cites W2067656314 @default.
• W2888290100 cites W2073725159 @default.
• W2888290100 cites W2078770871 @default.
• W2888290100 cites W2078899736 @default.
• W2888290100 cites W2086386648 @default.
• W2888290100 cites W2091422402 @default.
• W2888290100 cites W2096139859 @default.
• W2888290100 cites W2101005048 @default.
• W2888290100 cites W2103343452 @default.
• W2888290100 cites W2104325068 @default.
• W2888290100 cites W2109405741 @default.
• W2888290100 cites W2112428133 @default.
• W2888290100 cites W2113251371 @default.
• W2888290100 cites W2117123380 @default.
• W2888290100 cites W2123284622 @default.
• W2888290100 cites W2123912194 @default.
• W2888290100 cites W2124634096 @default.
• W2888290100 cites W2125255347 @default.
• W2888290100 cites W2125876865 @default.
• W2888290100 cites W2127679791 @default.
• W2888290100 cites W2130923181 @default.
• W2888290100 cites W2131068736 @default.
• W2888290100 cites W2134089325 @default.
• W2888290100 cites W2135697415 @default.
• W2888290100 cites W2139093911 @default.
• W2888290100 cites W2143456696 @default.
• W2888290100 cites W2143594833 @default.
• W2888290100 cites W2143861412 @default.
• W2888290100 cites W2144816096 @default.
• W2888290100 cites W2148621849 @default.
• W2888290100 cites W2148686938 @default.
• W2888290100 cites W2149050959 @default.
• W2888290100 cites W2151383900 @default.
• W2888290100 cites W2155925360 @default.
• W2888290100 cites W2157332661 @default.
• W2888290100 cites W2159811486 @default.
• W2888290100 cites W2166011336 @default.
• W2888290100 cites W2168640201 @default.
• W2888290100 cites W2170874271 @default.
• W2888290100 cites W2182554052 @default.
• W2888290100 cites W2235337769 @default.
• W2888290100 cites W2236474059 @default.
• W2888290100 cites W2240376148 @default.
• W2888290100 cites W2263606809 @default.
• W2888290100 cites W2264802137 @default.
• W2888290100 cites W2266475816 @default.
• W2888290100 cites W2315116899 @default.
• W2888290100 cites W2325480755 @default.
• W2888290100 cites W2333050857 @default.
• W2888290100 cites W2402608199 @default.
• W2888290100 cites W2404514818 @default.
• W2888290100 cites W2547042202 @default.
• W2888290100 cites W2581303875 @default.
• W2888290100 cites W2581369360 @default.
• W2888290100 cites W2581965723 @default.
• W2888290100 cites W2749415826 @default.
• W2888290100 cites W2775823361 @default.
• W2888290100 cites W2793611426 @default.
• W2888290100 cites W2950105280 @default.
• W2888290100 cites W2951479370 @default.
• W2888290100 cites W4235416980 @default.
• W2888290100 doi "https://doi.org/10.1016/j.meegid.2018.08.018" @default.
• W2888290100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6219893" @default.
• W2888290100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30145390" @default.
• W2888290100 hasPublicationYear "2018" @default.
• W2888290100 type Work @default.

• next