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• W2888403025 endingPage "e0202529" @default.
• W2888403025 startingPage "e0202529" @default.
• W2888403025 abstract "Paracoccidioides spp. is a thermally dimorphic fungus endemic to Latin America and the etiological agent of paracoccidioidomycosis (PCM), a granulomatous disease acquired through fungal propagule inhalation by its mammalian host. The infection is established after successful mycelia to yeast transition in the host pulmonary alveoli. The challenging environment inside the host exposes the fungus to the need of adaptation in order to circumvent nutritional, thermal, oxidative, immunological and other stresses that can directly affect their survival. Considering that autophagy is a response to abrupt environmental changes and is induced by stress conditions, this study hypothesizes that this process might be crucially involved in the adaptation of Paracoccidioides spp. to the host and, therefore, it is essential for the proper establishment of the disease. By labelling autophagous vesicles with monodansylcadaverine, autophagy was observed as an early event in cells during the normal mycelium to yeast transition, as well as in yeast cells of P. brasiliensis under glucose deprivation, and under either rapamycin or 3-methyladenine (3-MA). Findings in this study demonstrated that autophagy is triggered in P. brasiliensis during the thermal-induced mycelium to yeast transition and by glucose-limited conditions in yeasts, both of which modulated by rapamycin or 3-MA. Certainly, further genetic and in vivo analyses are needed in order to finally address the contribution of autophagy for adaptation. Yet, our data propose that autophagy possibly plays an important role in Paracoccidioides brasiliensis virulence and pathogenicity." @default.
• W2888403025 created "2018-08-31" @default.
• W2888403025 creator A5021425810 @default.
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• W2888403025 creator A5063779516 @default.
• W2888403025 date "2018-08-23" @default.
• W2888403025 modified "2023-10-14" @default.
• W2888403025 title "Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation" @default.
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• W2888403025 doi "https://doi.org/10.1371/journal.pone.0202529" @default.
• W2888403025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6107164" @default.
• W2888403025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30138387" @default.
• W2888403025 hasPublicationYear "2018" @default.
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