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- W2888408613 abstract "Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) is a negative modulatory signaling pathway for activation of T cell. It is acknowledged that PD-1/PD-L1 axis plays a crucial role in the progression of tumor by altering status of immune surveillance. As one of the most promising immune therapy strategies, PD-1/PD-L1 inhibitor is a breakthrough for the therapy of some refractory tumors. However, response rate of PD-1/PD-L1 inhibitors in overall patients is unsatisfactory, which limits the application in clinical practice. Therefore, biomarkers which could effectively predict the efficacy of PD-1/PD-L1 inhibitors are crucial for patient selection. Biomarkers reflecting tumor immune microenvironment and tumor cell intrinsic features, such as PD-L1 expression, density of tumor infiltrating lymphocyte (TIL), tumor mutational burden, and mismatch-repair (MMR) deficiency, have been noticed to associate with treatment effect of anti-PD-1/anti-PD-L1 therapy. Furthermore, gut microbiota, circulating biomarkers, and patient previous history have been found as valuable predictors as well. Therefore establishing a comprehensive assessment framework involving multiple biomarkers would be meaningful to interrogate tumor immune landscape and select sensitive patients." @default.
- W2888408613 created "2018-08-31" @default.
- W2888408613 creator A5000510528 @default.
- W2888408613 creator A5010134199 @default.
- W2888408613 creator A5044031959 @default.
- W2888408613 creator A5074864641 @default.
- W2888408613 creator A5075519052 @default.
- W2888408613 creator A5085143863 @default.
- W2888408613 creator A5087093116 @default.
- W2888408613 date "2018-08-23" @default.
- W2888408613 modified "2023-10-15" @default.
- W2888408613 title "Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors" @default.
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