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- W2888424856 abstract "Between the 1930s and 50s, evolutionary biologists developed a successful theory of why organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of aging had a secure experimental basis. Since the force of selection declines with age, aging evolves due to mutation accumulation or a benefit to fitness early in life. Here we review major insights and challenges that have emerged over the last 35 years: selection does not always necessarily decline with age; higher extrinsic (i.e., environmentally caused) mortality does not always accelerate aging; conserved pathways control aging rate; senescence patterns are more diverse than previously thought; aging is not universal; trade-offs involving lifespan can be 'broken'; aging might be 'druggable'; and human life expectancy continues to rise but compressing late-life morbidity remains a pressing challenge." @default.
- W2888424856 created "2018-08-31" @default.
- W2888424856 creator A5005084633 @default.
- W2888424856 creator A5059311261 @default.
- W2888424856 date "2018-08-20" @default.
- W2888424856 modified "2023-10-18" @default.
- W2888424856 title "Horizons in the evolution of aging" @default.
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