Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888479212> ?p ?o ?g. }
- W2888479212 abstract "Schizophrenia is considered a debilitating neurodevelopmental psychiatric disorder and its pharmacotherapy remains problematic without recent major advances. The development of interventions able to prevent the emergence of schizophrenia would therefore represent an enormous progress. Here, we investigated whether treatment with cannabidiol (CBD – a compound of Cannabis sativa that presents an antipsychotic profile in animals and humans) during peri-adolescence would prevent schizophrenia-like behavioral abnormalities in an animal model of schizophrenia: the Spontaneously Hypertensive Rat (SHR) strain. Wistar rats and SHRs were treated with vehicle or CBD from 30 to 60 post-natal days. In experiment 1, schizophrenia-like behaviors (locomotor activity, social interaction, prepulse inhibition of startle and contextual fear conditioning) were assessed on post-natal day 90. Side effects commonly associated with antipsychotic treatment were also evaluated: body weight gain and catalepsy throughout the treatment, and oral dyskinesia 48 hours after treatment interruption and on post-natal day 90. In experiment 2, serum levels of triglycerides and glycemia were assessed on post-natal day 61. In experiment 3, levels of BDNF, monoamines, and their metabolites were evaluated on post-natal days 61 and 90 in the prefrontal cortex and striatum. Treatment with CBD prevented the emergence of SHRs’ hyperlocomotor activity (a model for the positive symptoms of schizophrenia) and deficits in prepulse inhibition of startle and contextual fear conditioning (cognitive impairments). CBD did not induce any of the potential motor or metabolic side effects evaluated. Treatment with CBD increased the prefrontal cortex 5-HIAA/serotonin ratio and the levels of 5-HIAA on post-natal days 61 and 90, respectively. Our data provide pre-clinical evidence for a safe and beneficial effect of peripubertal and treatment with CBD on preventing positive and cognitive symptoms of schizophrenia, and suggest the involvement of the serotoninergic system on this effect." @default.
- W2888479212 created "2018-08-31" @default.
- W2888479212 creator A5016555206 @default.
- W2888479212 creator A5016964546 @default.
- W2888479212 creator A5017413992 @default.
- W2888479212 creator A5033435773 @default.
- W2888479212 creator A5037549528 @default.
- W2888479212 creator A5054036019 @default.
- W2888479212 creator A5057527534 @default.
- W2888479212 creator A5077848496 @default.
- W2888479212 creator A5078446428 @default.
- W2888479212 creator A5078846781 @default.
- W2888479212 creator A5085808647 @default.
- W2888479212 date "2018-08-21" @default.
- W2888479212 modified "2023-10-02" @default.
- W2888479212 title "Cannabidiol Administered During Peri-Adolescence Prevents Behavioral Abnormalities in an Animal Model of Schizophrenia" @default.
- W2888479212 cites W1166458116 @default.
- W2888479212 cites W1534457860 @default.
- W2888479212 cites W1555460522 @default.
- W2888479212 cites W1562709508 @default.
- W2888479212 cites W1958194583 @default.
- W2888479212 cites W1964176367 @default.
- W2888479212 cites W1964906165 @default.
- W2888479212 cites W1967281437 @default.
- W2888479212 cites W1972116107 @default.
- W2888479212 cites W1972281638 @default.
- W2888479212 cites W1972460604 @default.
- W2888479212 cites W1975682905 @default.
- W2888479212 cites W1983413649 @default.
- W2888479212 cites W1987936460 @default.
- W2888479212 cites W1991182005 @default.
- W2888479212 cites W1997812546 @default.
- W2888479212 cites W2005865251 @default.
- W2888479212 cites W2009735254 @default.
- W2888479212 cites W2015265008 @default.
- W2888479212 cites W2015650006 @default.
- W2888479212 cites W2020209931 @default.
- W2888479212 cites W2023923490 @default.
- W2888479212 cites W2027183477 @default.
- W2888479212 cites W2028287654 @default.
- W2888479212 cites W2029099271 @default.
- W2888479212 cites W2029118767 @default.
- W2888479212 cites W2030021261 @default.
- W2888479212 cites W2041192028 @default.
- W2888479212 cites W2047139719 @default.
- W2888479212 cites W2048548691 @default.
- W2888479212 cites W2052034283 @default.
- W2888479212 cites W2054070049 @default.
- W2888479212 cites W2056587727 @default.
- W2888479212 cites W2058844148 @default.
- W2888479212 cites W2061164005 @default.
- W2888479212 cites W2061517616 @default.
- W2888479212 cites W2062472783 @default.
- W2888479212 cites W2067530797 @default.
- W2888479212 cites W2069756682 @default.
- W2888479212 cites W2070367660 @default.
- W2888479212 cites W2072385006 @default.
- W2888479212 cites W2087282249 @default.
- W2888479212 cites W2090979638 @default.
- W2888479212 cites W2096003899 @default.
- W2888479212 cites W2107109664 @default.
- W2888479212 cites W2108240300 @default.
- W2888479212 cites W2108672634 @default.
- W2888479212 cites W2123403544 @default.
- W2888479212 cites W2123424261 @default.
- W2888479212 cites W2123923673 @default.
- W2888479212 cites W2128076336 @default.
- W2888479212 cites W2139078690 @default.
- W2888479212 cites W2140201388 @default.
- W2888479212 cites W2141645427 @default.
- W2888479212 cites W2149110258 @default.
- W2888479212 cites W2150647068 @default.
- W2888479212 cites W2150743419 @default.
- W2888479212 cites W2161416117 @default.
- W2888479212 cites W2168026843 @default.
- W2888479212 cites W2169269177 @default.
- W2888479212 cites W2169289621 @default.
- W2888479212 cites W2171054791 @default.
- W2888479212 cites W2171206543 @default.
- W2888479212 cites W2198642455 @default.
- W2888479212 cites W2220591944 @default.
- W2888479212 cites W2266843423 @default.
- W2888479212 cites W22872184 @default.
- W2888479212 cites W2345139695 @default.
- W2888479212 cites W2472577276 @default.
- W2888479212 cites W2473382229 @default.
- W2888479212 cites W2520483875 @default.
- W2888479212 cites W2525008462 @default.
- W2888479212 cites W2531790164 @default.
- W2888479212 cites W2533128384 @default.
- W2888479212 cites W2554974769 @default.
- W2888479212 cites W2555145513 @default.
- W2888479212 cites W2581837084 @default.
- W2888479212 cites W2591417478 @default.
- W2888479212 cites W2619979905 @default.
- W2888479212 cites W2693016255 @default.
- W2888479212 cites W2754703441 @default.
- W2888479212 cites W2772725445 @default.
- W2888479212 cites W2795424865 @default.
- W2888479212 cites W2801977187 @default.