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- W2888528022 endingPage "1937" @default.
- W2888528022 startingPage "1925" @default.
- W2888528022 abstract "Iron metabolism is a balancing act, and biological systems have evolved exquisite regulatory mechanisms to maintain iron homeostasis. Iron metabolism disorders are widespread health problems on a global scale and range from iron deficiency to iron-overload. Both types of iron disorders are linked to heart failure. Iron play a fundamental role in mitochondrial function and various enzyme functions and iron deficiency has a particular negative impact on mitochondria function. Given the high-energy demand of the heart, iron deficiency has a particularly negative impact on heart function and exacerbates heart failure. Iron-overload can result from excessive gut absorption of iron or frequent use of blood transfusions and is typically seen in patients with congenital anemias, sickle cell anemia and beta-thalassemia major, or in patients with primary hemochromatosis. This review provides an overview of normal iron metabolism, mechanisms underlying development of iron disorders in relation to heart failure, including iron-overload cardiomyopathy, and clinical perspective on the treatment options for iron metabolism disorders." @default.
- W2888528022 created "2018-08-31" @default.
- W2888528022 creator A5016151180 @default.
- W2888528022 creator A5049341927 @default.
- W2888528022 creator A5057401954 @default.
- W2888528022 creator A5086722810 @default.
- W2888528022 date "2019-07-01" @default.
- W2888528022 modified "2023-10-18" @default.
- W2888528022 title "Role of iron metabolism in heart failure: From iron deficiency to iron overload" @default.
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