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• W2888537772 abstract "Objectives Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old. Setting and Participants Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included. Measures The definition of sarcopenia was based on appendicular lean mass (ALM). Osteoporosis was diagnosed based on bone mineral density (BMD) T score. Four phenotypes were compared: (1) healthy body composition, that is, nonosteoporotic nonsarcopenic (CO, control group), (2) osteoporotic (O, low BMD T score), (3) sarcopenic (S, low ALM), and (4) osteosarcopenic (OS, low BMD T score and low ALM). Sex- and age-specific IGF1–Standard Deviation Scores (SDS) were calculated. The Continuous Scale–Physical Functional Performance (CS-PFP) test was performed. Results In OS men, IGF1-SDS values (−0.61 ±0.37 vs −0.04 ± 0.52, P = .02) were lower than those in CO males (control group), whereas IGF1-SDS were similar in the 4 body composition phenotypes in women. In men only, ALM was positively associated with IGF1-SDS values (P = .01) independent of age and C-reactive protein concentration. Regarding bone health, we found no association between IGF1-SDS values and BMD. IGF1-SDS was not associated with functional performance (CS-PFP) in men and women. Conclusions/Implications IGF1 sensitivity in skeletal muscle and bone may differ by sex in the oldest old. IGF1 status did not appear to affect physical functionality. Determinants and clinical and functional characteristics of osteosarcopenia need to be further investigated in order to define conclusive diagnostic criteria." @default.
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• W2888537772 date "2019-01-01" @default.
• W2888537772 modified "2023-10-14" @default.
• W2888537772 title "Body Composition, IGF1 Status, and Physical Functionality in Nonagenarians: Implications for Osteosarcopenia" @default.
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• W2888537772 doi "https://doi.org/10.1016/j.jamda.2018.07.007" @default.
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