Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888567911> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2888567911 abstract "Cancer is the second leading cause of death in the United States and few treatments offer a panacea for all the various types of cancer that exist. Certain superparamagnetic iron oxide nanoparticles (SPIONs) are FDA-approved as contrast agents in magnetic resonance imaging while the potential applications for SPIONs are numerous. One such application is magnetic hyperthermia (MH) where alternating magnetic fields applied to SPIONs generate heat. MH in treating cancer would cause cancer cells to deteriorate from the inside without the use of strong chemotherapeutics. SPION effectiveness is hindered by the low uptake in cancer cells and the generation of reactive oxygen species that cause harm to the healthy cells in the body. In early studies, healthy, primary mouse kidney and lung fibroblasts had an increased uptake of iron oxide nanoparticles (IONs) versus human brain cancer cells (E297 and U87) and mouse osteosarcomas (K7M2.) Hydroxyapatite (HAP), the primary ceramic in our bones, offers a solution to SPION delivery. HAP particles are commended as a biomaterial for their biodegradability and biocompatibility, and their use as a nonviral transfection agent. Dispersing IONS in HAP nanoparticles could increase the uptake in cancer cells and minimize the risk to healthy cells. The goal of this work is the construction and characterization of a hydroxyapatite-iron oxide nanocomposite (HAP-ION) usable as a device for magnetic hyperthermia, minimizing the risk to healthy cells and increasing their uptake in cancer cells. HAP-IONs retain the superparamagnetic nature of IONs, have increased uptake in cancer cells versus their ION counterparts, reduce cancer cell viability and primary cancer spheroid migration, and maintain the viability of healthy human mesenchymal stem cells (hMSCs). Further analysis of actin cytoskeleton revealed that healthy hMSCs have a reduced anisotropy in their cytoskeleton arrangement after the uptake of IONs, while primary cancerous cells have an increased anisotropy in cytoskeleton arrangement after the uptake of IONs. Nanocomposites of hydroxyapatite and IONs open a new avenue to cancer therapies that utilize MH." @default.
- W2888567911 created "2018-08-31" @default.
- W2888567911 creator A5084105511 @default.
- W2888567911 date "2016-11-28" @default.
- W2888567911 modified "2023-09-27" @default.
- W2888567911 title "Effects of Hydroxyapatite-Iron Oxide Nanocomposite Against Human Glioblastoma Cells" @default.
- W2888567911 hasPublicationYear "2016" @default.
- W2888567911 type Work @default.
- W2888567911 sameAs 2888567911 @default.
- W2888567911 citedByCount "0" @default.
- W2888567911 crossrefType "dissertation" @default.
- W2888567911 hasAuthorship W2888567911A5084105511 @default.
- W2888567911 hasConcept C121608353 @default.
- W2888567911 hasConcept C12554922 @default.
- W2888567911 hasConcept C126322002 @default.
- W2888567911 hasConcept C136229726 @default.
- W2888567911 hasConcept C155672457 @default.
- W2888567911 hasConcept C171250308 @default.
- W2888567911 hasConcept C185592680 @default.
- W2888567911 hasConcept C191897082 @default.
- W2888567911 hasConcept C192562407 @default.
- W2888567911 hasConcept C2777230088 @default.
- W2888567911 hasConcept C2777697756 @default.
- W2888567911 hasConcept C2778889443 @default.
- W2888567911 hasConcept C2779949491 @default.
- W2888567911 hasConcept C2780838151 @default.
- W2888567911 hasConcept C502942594 @default.
- W2888567911 hasConcept C71924100 @default.
- W2888567911 hasConcept C86803240 @default.
- W2888567911 hasConcept C87023908 @default.
- W2888567911 hasConcept C92880739 @default.
- W2888567911 hasConcept C96232424 @default.
- W2888567911 hasConceptScore W2888567911C121608353 @default.
- W2888567911 hasConceptScore W2888567911C12554922 @default.
- W2888567911 hasConceptScore W2888567911C126322002 @default.
- W2888567911 hasConceptScore W2888567911C136229726 @default.
- W2888567911 hasConceptScore W2888567911C155672457 @default.
- W2888567911 hasConceptScore W2888567911C171250308 @default.
- W2888567911 hasConceptScore W2888567911C185592680 @default.
- W2888567911 hasConceptScore W2888567911C191897082 @default.
- W2888567911 hasConceptScore W2888567911C192562407 @default.
- W2888567911 hasConceptScore W2888567911C2777230088 @default.
- W2888567911 hasConceptScore W2888567911C2777697756 @default.
- W2888567911 hasConceptScore W2888567911C2778889443 @default.
- W2888567911 hasConceptScore W2888567911C2779949491 @default.
- W2888567911 hasConceptScore W2888567911C2780838151 @default.
- W2888567911 hasConceptScore W2888567911C502942594 @default.
- W2888567911 hasConceptScore W2888567911C71924100 @default.
- W2888567911 hasConceptScore W2888567911C86803240 @default.
- W2888567911 hasConceptScore W2888567911C87023908 @default.
- W2888567911 hasConceptScore W2888567911C92880739 @default.
- W2888567911 hasConceptScore W2888567911C96232424 @default.
- W2888567911 hasLocation W28885679111 @default.
- W2888567911 hasOpenAccess W2888567911 @default.
- W2888567911 hasPrimaryLocation W28885679111 @default.
- W2888567911 hasRelatedWork W1998522600 @default.
- W2888567911 hasRelatedWork W2018173850 @default.
- W2888567911 hasRelatedWork W2020425473 @default.
- W2888567911 hasRelatedWork W2035093523 @default.
- W2888567911 hasRelatedWork W2055971321 @default.
- W2888567911 hasRelatedWork W2089548655 @default.
- W2888567911 hasRelatedWork W2141862632 @default.
- W2888567911 hasRelatedWork W2155432159 @default.
- W2888567911 hasRelatedWork W2161450478 @default.
- W2888567911 hasRelatedWork W2167728247 @default.
- W2888567911 hasRelatedWork W2314963232 @default.
- W2888567911 hasRelatedWork W2485809784 @default.
- W2888567911 hasRelatedWork W2567196260 @default.
- W2888567911 hasRelatedWork W2809516199 @default.
- W2888567911 hasRelatedWork W2967881669 @default.
- W2888567911 hasRelatedWork W2997866046 @default.
- W2888567911 hasRelatedWork W3136543587 @default.
- W2888567911 hasRelatedWork W3173571029 @default.
- W2888567911 hasRelatedWork W3194322946 @default.
- W2888567911 hasRelatedWork W3209868520 @default.
- W2888567911 isParatext "false" @default.
- W2888567911 isRetracted "false" @default.
- W2888567911 magId "2888567911" @default.
- W2888567911 workType "dissertation" @default.