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• W2888572224 endingPage "944" @default.
• W2888572224 startingPage "937" @default.
• W2888572224 abstract "The prevalence of Candida infection induced by non-albicans Candida (NAC) species is increasing. However, as a common NAC species, C. tropicalis has received much less study in terms of host immunity than C. albicans has. In this study, we evaluated the pro-inflammatory cytokine responses evoked by C. tropicalis and determined whether dectin-1 and downstream NF-κB and mitogen-activated protein kinases (MAPKs) signaling pathways played roles in inflammation in human peripheral blood mononuclear cells (PBMCs) and THP-1 macrophage-like cells. Exposure of PBMCs and THP-1 macrophage-like cells to C. tropicalis led to the enhanced gene expression and secretion of TNF-α and IL-6 in a time- and dose-dependent manner. THP-1 macrophage-like cells being challenged by C. tropicalis resulted in the activation of the NF-κB, p38, and ERK1/2 MAPK signaling pathways. We also found that the expression of dectin-1 was increased with C. tropicalis treatment. These data reveal that dectin-1 may play a role in sensing the inflammation response induced by C. tropicalis and that NF-κB and MAPK are involved in the downstream signaling pathways in macrophages." @default.
• W2888572224 created "2018-08-31" @default.
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• W2888572224 date "2018-12-01" @default.
• W2888572224 modified "2023-09-27" @default.
• W2888572224 title "<i>Candida tropicalis</i> induces pro-inflammatory cytokine production, NF-κB and MAPKs pathways regulation, and dectin-1 activation" @default.
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• W2888572224 doi "https://doi.org/10.1139/cjm-2017-0559" @default.
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