FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888603931> ?p ?o ?g. }

• W2888603931 endingPage "189" @default.
• W2888603931 startingPage "180" @default.
• W2888603931 abstract "Mechanisms underlying oral immunotherapy (OIT) are unclear and the effects on immune cells at varying maintenance doses are unknown.We aimed to determine the immunologic changes caused by peanut OIT in preschool aged children and determine the effect on these immune responses in groups ingesting low or high-dose peanut OIT (300 mg or 3000 mg, respectively) as maintenance therapy.Blood was drawn at several time-points throughout the OIT protocol and PBMCs isolated and cultured with peanut antigens. Secreted cytokines were quantified via multiplex assay, whereas Treg and peanut-responsive CD4 T cells were studied with flow cytometry. Basophil activation assays were also conducted.Th2-, Th1-, Th9- and Tr1-type cytokines decreased over the course of OIT in groups on high- and low-dose OIT. There were no significant differences detected in cytokine changes between the high- and low-dose groups. The initial increase in both the number of peanut-responsive CD4 T cells and the number of Tregs was transient and no significant differences were found between groups. Basophil activation following peanut stimulation was decreased over the course of OIT and associated with increased peanut-IgG4/IgE ratios. No differences were found between high- and low-dose groups in basophil activation at the time of desensitization or sustained unresponsiveness oral food challenges.Peanut OIT leads to decreases in pro-allergic cytokines, including IL-5, IL-13, and IL-9 and decreased basophil activation. No differences in T cell or basophil responses were found between subjects on low or high-dose maintenance OIT, which has implications for clinical dosing strategies." @default.
• W2888603931 created "2018-08-31" @default.
• W2888603931 creator A5023002726 @default.
• W2888603931 creator A5024562320 @default.
• W2888603931 creator A5034220226 @default.
• W2888603931 creator A5038351700 @default.
• W2888603931 creator A5040856684 @default.
• W2888603931 creator A5047262526 @default.
• W2888603931 creator A5048531900 @default.
• W2888603931 creator A5056353600 @default.
• W2888603931 creator A5058536666 @default.
• W2888603931 creator A5062901617 @default.
• W2888603931 creator A5076252230 @default.
• W2888603931 date "2018-09-18" @default.
• W2888603931 modified "2023-10-12" @default.
• W2888603931 title "High- and low-dose oral immunotherapy similarly suppress pro-allergic cytokines and basophil activation in young children" @default.
• W2888603931 cites W1963754158 @default.
• W2888603931 cites W1969953062 @default.
• W2888603931 cites W1989628032 @default.
• W2888603931 cites W1991468826 @default.
• W2888603931 cites W1991498260 @default.
• W2888603931 cites W1994095603 @default.
• W2888603931 cites W2012513978 @default.
• W2888603931 cites W2022764839 @default.
• W2888603931 cites W2027046805 @default.
• W2888603931 cites W2053628920 @default.
• W2888603931 cites W2055861246 @default.
• W2888603931 cites W2061228058 @default.
• W2888603931 cites W2079909497 @default.
• W2888603931 cites W2089079043 @default.
• W2888603931 cites W2133827756 @default.
• W2888603931 cites W2138476409 @default.
• W2888603931 cites W2148903359 @default.
• W2888603931 cites W2158043711 @default.
• W2888603931 cites W2162344297 @default.
• W2888603931 cites W2264217430 @default.
• W2888603931 cites W2319898578 @default.
• W2888603931 cites W2326183777 @default.
• W2888603931 cites W2491611941 @default.
• W2888603931 cites W3112717819 @default.
• W2888603931 cites W4253220851 @default.
• W2888603931 doi "https://doi.org/10.1111/cea.13256" @default.
• W2888603931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6353702" @default.
• W2888603931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30126028" @default.
• W2888603931 hasPublicationYear "2018" @default.
• W2888603931 type Work @default.
• W2888603931 sameAs 2888603931 @default.
• W2888603931 citedByCount "41" @default.
• W2888603931 countsByYear W28886039312019 @default.
• W2888603931 countsByYear W28886039312020 @default.
• W2888603931 countsByYear W28886039312021 @default.
• W2888603931 countsByYear W28886039312022 @default.
• W2888603931 countsByYear W28886039312023 @default.
• W2888603931 crossrefType "journal-article" @default.
• W2888603931 hasAuthorship W2888603931A5023002726 @default.
• W2888603931 hasAuthorship W2888603931A5024562320 @default.
• W2888603931 hasAuthorship W2888603931A5034220226 @default.
• W2888603931 hasAuthorship W2888603931A5038351700 @default.
• W2888603931 hasAuthorship W2888603931A5040856684 @default.
• W2888603931 hasAuthorship W2888603931A5047262526 @default.
• W2888603931 hasAuthorship W2888603931A5048531900 @default.
• W2888603931 hasAuthorship W2888603931A5056353600 @default.
• W2888603931 hasAuthorship W2888603931A5058536666 @default.
• W2888603931 hasAuthorship W2888603931A5062901617 @default.
• W2888603931 hasAuthorship W2888603931A5076252230 @default.
• W2888603931 hasBestOaLocation W28886039311 @default.
• W2888603931 hasConcept C126322002 @default.
• W2888603931 hasConcept C137061746 @default.
• W2888603931 hasConcept C141105273 @default.
• W2888603931 hasConcept C159654299 @default.
• W2888603931 hasConcept C170493617 @default.
• W2888603931 hasConcept C202751555 @default.
• W2888603931 hasConcept C203014093 @default.
• W2888603931 hasConcept C2776203516 @default.
• W2888603931 hasConcept C2777456892 @default.
• W2888603931 hasConcept C2777701055 @default.
• W2888603931 hasConcept C2778690821 @default.
• W2888603931 hasConcept C2779176990 @default.
• W2888603931 hasConcept C2779779143 @default.
• W2888603931 hasConcept C3018710434 @default.
• W2888603931 hasConcept C553184892 @default.
• W2888603931 hasConcept C55493867 @default.
• W2888603931 hasConcept C71924100 @default.
• W2888603931 hasConcept C86803240 @default.
• W2888603931 hasConcept C8891405 @default.
• W2888603931 hasConceptScore W2888603931C126322002 @default.
• W2888603931 hasConceptScore W2888603931C137061746 @default.
• W2888603931 hasConceptScore W2888603931C141105273 @default.
• W2888603931 hasConceptScore W2888603931C159654299 @default.
• W2888603931 hasConceptScore W2888603931C170493617 @default.
• W2888603931 hasConceptScore W2888603931C202751555 @default.
• W2888603931 hasConceptScore W2888603931C203014093 @default.
• W2888603931 hasConceptScore W2888603931C2776203516 @default.
• W2888603931 hasConceptScore W2888603931C2777456892 @default.
• W2888603931 hasConceptScore W2888603931C2777701055 @default.
• W2888603931 hasConceptScore W2888603931C2778690821 @default.
• W2888603931 hasConceptScore W2888603931C2779176990 @default.
• W2888603931 hasConceptScore W2888603931C2779779143 @default.

• next