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- W2888606891 abstract "Summary Bendamustine is used in combination with rituximab ( BR ) to treat indolent non‐Hodgkin lymphomas ( iNHL ) and mantle cell lymphoma ( MCL ). The variability in treatment efficacy and toxicity could be related to single nucleotide polymorphisms ( SNP s) in immune response genes. We would like to show a correlation between SNP s and treatment outcome in iNHL and MCL patients receiving BR . We investigated some SNP s that had already been associated with NHL outcome. Samples were genotyped for the IL 2 (rs2069762), IL 10 (rs1800890, rs10494879), VEGFA (rs3025039), IL 8 (rs4073), CFH (rs1065489) and MTHFR (rs1801131) SNP s by allelic discrimination assays. We enrolled 70 patients that received rituximab 375 mg/m 2 and bendamustine 90 mg/m 2 every 28 days, both as first‐line treatment and ≥ second‐line regimens. Overall response rate was 97·1% (complete response [ CR ] rate 73·9%). Treatment toxicity included grade 3–4 neutropenia (24/70 patients), infections (21/70 patients; 1/70 grade 3), skin rash (26/70 patients; 2/70 grade 3). After a median follow‐up of 24 months we did find any correlation between the analysed SNP s, CR rate and PFS . However, we demonstrated an association between the SNP in IL 2 (rs2069762) and the onset of skin rash ( P = 0·0001). Our study suggests a role for cytokine SNP s in bendamustine‐related toxicity, which could represent a promising research field." @default.
- W2888606891 created "2018-08-31" @default.
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- W2888606891 date "2018-09-11" @default.
- W2888606891 modified "2023-10-18" @default.
- W2888606891 title "Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with indolent non‐hodgkin lymphomas and mantle cell lymphoma receiving bendamustine and rituximab" @default.
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- W2888606891 doi "https://doi.org/10.1111/bjh.15582" @default.
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