FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2888623855> ?p ?o ?g. }

• W2888623855 abstract "Abstract Amblyopia is a common visual disorder that is treatable in childhood. However, therapies have limited efficacy in adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision in adult rats with amblyopia. We conducted a Phase 2, randomized (fluoxetine vs. placebo), double-blind, multicenter clinical trial examined whether or not fluoxetine can improve visual acuity in amblyopic adults. This interventional trial included 42 participants diagnosed with moderate to severe amblyopia. Subjects were randomized to receive either 20 mg fluoxetine (n = 22) or placebo (n = 20). During the 10-week treatment period, all subjects performed daily computerized perceptual training and eye patching. At the primary endpoint, the mean treatment group difference in visual acuity improvement was only 0.027 logMAR units (95% CI: −0.057 to 0.110; p = 0.524). However, visual acuity had significantly improved from baseline to 10 weeks in both fluoxetine (−0.167 logMAR; 95% CI: −0.226 to −0.108; p < 0.001) and placebo (−0.194 logMAR; 95% CI: −0.254 to −0.133; p < 0.001) groups. While this study failed to provide evidence that fluoxetine enhances neuroplasticity, our data support other recent clinical studies suggesting that improvement of vision can be accomplished in adults with amblyopia." @default.
• W2888623855 created "2018-08-31" @default.
• W2888623855 creator A5007347334 @default.
• W2888623855 creator A5014627042 @default.
• W2888623855 creator A5018873305 @default.
• W2888623855 creator A5019744869 @default.
• W2888623855 creator A5033398262 @default.
• W2888623855 creator A5045356137 @default.
• W2888623855 creator A5050133862 @default.
• W2888623855 creator A5056016003 @default.
• W2888623855 creator A5064207133 @default.
• W2888623855 creator A5070631772 @default.
• W2888623855 date "2018-08-27" @default.
• W2888623855 modified "2023-10-10" @default.
• W2888623855 title "Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia" @default.
• W2888623855 cites W1527708762 @default.
• W2888623855 cites W1589486570 @default.
• W2888623855 cites W1903213774 @default.
• W2888623855 cites W1965895731 @default.
• W2888623855 cites W1969166506 @default.
• W2888623855 cites W1970624988 @default.
• W2888623855 cites W1970690033 @default.
• W2888623855 cites W197230158 @default.
• W2888623855 cites W1979358850 @default.
• W2888623855 cites W1979469164 @default.
• W2888623855 cites W1979818862 @default.
• W2888623855 cites W1980353041 @default.
• W2888623855 cites W1987177929 @default.
• W2888623855 cites W1988993555 @default.
• W2888623855 cites W1998823101 @default.
• W2888623855 cites W1998958515 @default.
• W2888623855 cites W1999149589 @default.
• W2888623855 cites W2013377646 @default.
• W2888623855 cites W2017099176 @default.
• W2888623855 cites W2018955711 @default.
• W2888623855 cites W2022555874 @default.
• W2888623855 cites W2028235729 @default.
• W2888623855 cites W2033862119 @default.
• W2888623855 cites W2040700047 @default.
• W2888623855 cites W2051423370 @default.
• W2888623855 cites W2052197868 @default.
• W2888623855 cites W2055591199 @default.
• W2888623855 cites W2057809729 @default.
• W2888623855 cites W2067359003 @default.
• W2888623855 cites W2082407289 @default.
• W2888623855 cites W20945231 @default.
• W2888623855 cites W2100973921 @default.
• W2888623855 cites W2103979872 @default.
• W2888623855 cites W2104220712 @default.
• W2888623855 cites W2105500446 @default.
• W2888623855 cites W2115316918 @default.
• W2888623855 cites W2116836378 @default.
• W2888623855 cites W2118911490 @default.
• W2888623855 cites W2124038949 @default.
• W2888623855 cites W2132542538 @default.
• W2888623855 cites W2136951666 @default.
• W2888623855 cites W2148484573 @default.
• W2888623855 cites W2157172876 @default.
• W2888623855 cites W2522076937 @default.
• W2888623855 cites W2539307022 @default.
• W2888623855 cites W2781957004 @default.
• W2888623855 cites W2792218378 @default.
• W2888623855 cites W3027330476 @default.
• W2888623855 cites W4250405605 @default.
• W2888623855 cites W49123541 @default.
• W2888623855 cites W97765374 @default.
• W2888623855 doi "https://doi.org/10.1038/s41598-018-31169-z" @default.
• W2888623855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6110780" @default.
• W2888623855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30150750" @default.
• W2888623855 hasPublicationYear "2018" @default.
• W2888623855 type Work @default.
• W2888623855 sameAs 2888623855 @default.
• W2888623855 citedByCount "15" @default.
• W2888623855 countsByYear W28886238552019 @default.
• W2888623855 countsByYear W28886238552020 @default.
• W2888623855 countsByYear W28886238552021 @default.
• W2888623855 countsByYear W28886238552022 @default.
• W2888623855 countsByYear W28886238552023 @default.
• W2888623855 crossrefType "journal-article" @default.
• W2888623855 hasAuthorship W2888623855A5007347334 @default.
• W2888623855 hasAuthorship W2888623855A5014627042 @default.
• W2888623855 hasAuthorship W2888623855A5018873305 @default.
• W2888623855 hasAuthorship W2888623855A5019744869 @default.
• W2888623855 hasAuthorship W2888623855A5033398262 @default.
• W2888623855 hasAuthorship W2888623855A5045356137 @default.
• W2888623855 hasAuthorship W2888623855A5050133862 @default.
• W2888623855 hasAuthorship W2888623855A5056016003 @default.
• W2888623855 hasAuthorship W2888623855A5064207133 @default.
• W2888623855 hasAuthorship W2888623855A5070631772 @default.
• W2888623855 hasBestOaLocation W28886238551 @default.
• W2888623855 hasConcept C118487528 @default.
• W2888623855 hasConcept C126322002 @default.
• W2888623855 hasConcept C142724271 @default.
• W2888623855 hasConcept C15744967 @default.
• W2888623855 hasConcept C168563851 @default.
• W2888623855 hasConcept C169760540 @default.
• W2888623855 hasConcept C170493617 @default.
• W2888623855 hasConcept C203092338 @default.
• W2888623855 hasConcept C204787440 @default.
• W2888623855 hasConcept C22033958 @default.

• next