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- W2888638251 abstract "Two men were admitted following generalized seizures. Cerebral MRI-scans showed multiple independent enhancing lesions which were bilateral (first case) and unilateral but disseminated to the brainstem (second case). Whole-body CT-scans showed no primaries. Both cases were diagnosed by biopsy as IDH1 wild-type multicentric glioblastoma. Treatment of both was palliative. The natural history of this entity remains matter of debate but 2 genomic analysis strikingly revealed that foci from the same patient were of monoclonal origin. Consistently, these 2 cases could sustain the hypothesis that an anatomical connectivity exists between the different foci of a multicentric glioblastoma." @default.
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- W2888638251 date "2018-08-23" @default.
- W2888638251 modified "2023-10-14" @default.
- W2888638251 title "The enigma of multicentric glioblastoma: physiopathogenic hypothesis and discussion about two cases" @default.
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- W2888638251 doi "https://doi.org/10.1080/02688697.2018.1501465" @default.
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