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• W2888649842 abstract "N-Functionalized amino acids are important building blocks for the preparation of diverse bioactive molecules, including peptides. The development of sustainable manufacturing routes to chiral N-alkylated amino acids remains a significant challenge in the pharmaceutical and fine-chemical industries. Herein we report the discovery of a structurally diverse panel of biocatalysts which catalyze the asymmetric synthesis of N-alkyl amino acids through the reductive coupling of ketones and amines. Reactions have been performed on a gram scale to yield optically pure N-alkyl-functionalized products in high yields." @default.
• W2888649842 created "2018-08-31" @default.
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• W2888649842 date "2018-10-15" @default.
• W2888649842 modified "2023-09-27" @default.
• W2888649842 title "Biocatalytic Synthesis of Chiral N‐Functionalized Amino Acids" @default.
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• W2888649842 doi "https://doi.org/10.1002/anie.201806893" @default.
• W2888649842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30138551" @default.
• W2888649842 hasPublicationYear "2018" @default.
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