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• W2888695170 abstract "We examined the potential role of polymorphisms of the platelet genes GP1BA (rs2243093, rs6065 and VNTR), ITGB3 (rs5918), ITGA2 (rs938043469) and P2RY12 (rs2046934, rs6801273 and rs6798347) as risk factors for myocardial infarction (MI). The study population was divided into three groups: controls (n=235), MI at age ≤45 years (MI ≤45, n=44), and MI at age >45 years (MI >45, n=78). The control group was further divided into two subgroups (control ≤45 and >45), and subgroups including only men were also considered for statistical analysis. Polymorphisms were detected by polymerase chain reaction and restriction fragment length polymorphism analysis. Regarding non-genetic risk factors, the control group differed statistically from the MI ≤45 group (p<00.5) in terms of smoking, hypertension, diabetes and obesity, and from the MI >45 group (p<0.05) in terms of hypertension, diabetes, obesity, family history of thrombosis and high cholesterol. For the studied ITGA2 polymorphism, a statistical difference was found when MI >45 was compared with the control group, with a higher risk of MI in the TT genotype (OR 2.852; 95% CI: 1.092-7.451; p=0.032). In the GP1BA rs6065 polymorphism, a statistically significant difference was found between control ≤45 only men and MI ≤45 only men, with a higher risk in the CT genotype (OR 5.568; 95% CI: 1.421-21.822; p=0.016), despite the low numbers included. The other polymorphisms studied did not show any statistically significant correlations. There is a statistically significant association between the TT genotype of the ITGA2 rs938043469 polymorphism and increased risk for MI >45. Determinou-se o papel de polimorfismos dos genes de expressão plaquetária GP1BA (rs2243093, rs6065 e o VNTR p.Ser415_Thr428(0_4)), ITGB3 (rs5918), ITGA2 (rs938043469) e P2RY12 (rs2046934, rs6801273 e rs6798347) como fatores de risco para o enfarte agudo do miocárdio (EAM). A amostra foi dividida em três grupos: Controlo (n=235), EAM ≤45 anos (n=44) e EAM >45 anos (n=78). O grupo Controlo foi ainda dividido em dois subgrupos (Controlo ≤45 e >45). Subgrupos incluindo somente homens também foram considerados para fins estatísticos. Os polimorfismos foram estudados através de PCR e RFLP. Em relação aos fatores de risco não genéticos, o grupo Controlo diferia estatisticamente do grupo EAM ≤ 45 anos (p<0,05) em termos de hábitos tabágicos, hipertensão, diabetes e obesidade e também diferia do grupo EAM >45 anos (p<0,05) nas variáveis hipertensão, diabetes, obesidade, antecedentes familiares de trombose e colesterol. Para o polimorfismo estudado do gene ITGA2, verificou-se uma diferença estatisticamente significativa quando se compararam os grupos EAM >45 anos e Controlo, associando-se o genótipo TT a aumento de risco de EAM (OR 2,852; IC 95% de 1,092 a 7,451; p=0,032). No polimorfismo rs6065 do gene GP1BA foi encontrada uma diferença estatística quando comparados os grupos Controlo ≤ 45 só homens e EAM ≤ 45 só homens, associando-se o genótipo C/T a um maior risco de EAM (OR 5,568; IC 95% de 1,421 a 21,822; p=0,016), apesar do baixo n. Os outros polimorfismos não apresentaram correlação significativa. Existe uma associação estatística significativa entre o genótipo T/T do polimorfismo rs938043469 do gene ITGA2 e o risco de EAM >45." @default.
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• W2888695170 date "2018-09-01" @default.
• W2888695170 modified "2023-10-18" @default.
• W2888695170 title "Myocardial infarction before and after the age of 45: Possible role of platelet receptor polymorphisms" @default.
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• W2888695170 cites W1992995409 @default.
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• W2888695170 cites W2005007281 @default.
• W2888695170 cites W2005971263 @default.
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• W2888695170 cites W2013984455 @default.
• W2888695170 cites W2030218174 @default.
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• W2888695170 cites W2048765369 @default.
• W2888695170 cites W2051306824 @default.
• W2888695170 cites W2055488118 @default.
• W2888695170 cites W2055615517 @default.
• W2888695170 cites W2061033958 @default.
• W2888695170 cites W2073409551 @default.
• W2888695170 cites W2079270260 @default.
• W2888695170 cites W2083102596 @default.
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• W2888695170 doi "https://doi.org/10.1016/j.repc.2018.03.015" @default.
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