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• W2888737251 abstract "<b><i>Background/Aims:</i></b> The SYNERGY (Saizen® for Your New Life and Brighter Tomorrow without Growth Deficiency) study is the first randomised multi-centre, open-label study to assess the short-term efficacy and safety of this recombinant human growth hormone (r-hGH) preparation for prepubertal children with idiopathic short stature in South Korea. <b><i>Methods:</i></b> The SYNERGY study (ClinicalTrials.gov NCT01746862) was conducted at 9 centres throughout South Korea between December 2012 and March 2015. The primary endpoint was difference in height velocity from baseline to 6 months in the treatment and control arms. <b><i>Results:</i></b> 97 children were screened; 90 were randomly assigned: 60 children to 0.067 mg/kg/day r-hGH for 12 months (treatment) and 30 children to 6 months of no treatment followed by 0.067 mg/kg/day r-hGH for 6 months (control). The 6-month mean height velocity in the treatment group increased from 5.63 cm/year (SD 1.62) to 10.08 cm/year (SD 1.92) (<i>p</i> &#x3c; 0.0001) and from 4.94 cm/year (SD 1.91) to 5.92 cm/year (SD 2.01) (<i>p</i> = 0.0938) in the control group (between-group difference 3.47 cm/year, 95% CI 2.17–4.78; <i>p</i> &#x3c; 0.0001). Adherence was &#x3e; 90% throughout the study. The safety profile was consistent with that already known for r-hGH. <b><i>Conclusion:</i></b> Treatment with r-hGH in the SYNERGY study demonstrated a statistically significant increase in height velocity at 6 months." @default.
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• W2888737251 date "2018-01-01" @default.
• W2888737251 modified "2023-10-06" @default.
• W2888737251 title "Effect of Growth Hormone Therapy on Height Velocity in Korean Children with Idiopathic Short Stature: A Phase III Randomised Controlled Trial" @default.
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• W2888737251 doi "https://doi.org/10.1159/000491016" @default.
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