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- W2888762031 endingPage "54" @default.
- W2888762031 startingPage "41" @default.
- W2888762031 abstract "Heart failure is a complex clinical syndrome associated with a significant morbidity and mortality burden. Reductions in left ventricular (LV) function trigger adaptive mechanisms, leading to structural changes within the LV and the potential development of dyssynchronous ventricular activation. This is the substrate targeted during cardiac resynchronisation therapy (CRT); however, around 30–50% of patients do not experience benefit from this treatment. Non-response occurs as a result of pre-implant, peri-implant and post implant factors but the technical constraints of traditional, transvenous epicardial CRT mean they can be challenging to overcome. In an effort to improve response, novel alternative methods of CRT delivery have been developed and of these endocardial pacing, where the LV is stimulated from inside the LV cavity, appears the most promising." @default.
- W2888762031 created "2018-08-31" @default.
- W2888762031 creator A5003882320 @default.
- W2888762031 creator A5022133771 @default.
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- W2888762031 creator A5039500853 @default.
- W2888762031 creator A5068890461 @default.
- W2888762031 creator A5087088356 @default.
- W2888762031 date "2018-08-24" @default.
- W2888762031 modified "2023-10-02" @default.
- W2888762031 title "Understanding non-response to cardiac resynchronisation therapy: common problems and potential solutions" @default.
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