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- W2888772614 abstract "The classic coagulation analyses based on the clot formation present basic disadvantages which make a standardization of reagents difficult. The use of photometry for coagulation methods represents nowadays an important step towards test optimization. We have evaluated a new analytical system (ChromoTimeSystem, Behringwerke AG, Marburg/FRG) based on a special instrument and reagents for photometric tests for coagulation and fibrinolysis. The instrument is a microprocessor-controlled 4-channel-photometer operating at 37°C and connected to a microcomputer. Photometric methods for prothrombin time (PT: Chromoquick®) and activated partial thromboplastin time (aPTT: Partochrom®) have been developed using a new chromogenic substrate (Tos-Gly-Pro-Arg-5-amino-2-nitro-benzoic-acid-isopropy-lamide) specific for thrombin. These tests are based on the time necessary to attain a fixed increase of absorbance (0.1 A). Tests for thrombin time (TT), batroxobin time and fibrinogen rely on turbidimetric techniques. In the screening tests PT, aPTT and fibrinogen 25 μl sample (TT: 50 μl) and 250 μl reagent are used. Single coagulation factors are assayed by mixing an undiluted sample (10 μl) with the correspondent factor deficient plasma (50 μl) in connection with the chromogenic PT or aPTT reagent (500 μl). The evaluated specific chromogenic substrate methods are: antithrombin III, α2-antiplasmin and plasminogen. Tne characteristics of the ChromoTimeSystem are: fibrinogen-independent PT and PTT, small sample volumes (10-50 μl), no predilution or preincubation, PT standardization according to WHO recommendations, coefficients of variation between 1 and 4 %, good correlation between photometric and coagulometric tests, the reference values for photom. PTT being 90-120 sec." @default.
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- W2888772614 date "1987-01-01" @default.
- W2888772614 modified "2023-09-25" @default.
- W2888772614 title "RESULTS OF THE MULTICENTRIC EVALUATION OF A NEW SYSTEM FOR PHOTOMETRIC DETERMINATION OF COAGULATION PARAMETERS" @default.
- W2888772614 doi "https://doi.org/10.1055/s-0038-1643258" @default.
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