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- W2888779963 abstract "Inactivation of thrombin which occurs mainly on the endothelium requires binding of the enzyme to receptors on the endothelial cells. One receptor for thrombin is glycosaminoglycans (GAG). Antithrombin (AT), however, also binds to GAG and may be involved in endothelial inactivation of thrombin. The purpose of the present study was to study the role of AT for the inhibition of thrombin on endothelium. The experiments were performed on rabbit aorta segment in vitro. Thrombin in solution and on the endothelial surface was functionally assayed with aid of a synthetic chromogenic substrate (thrombinS) or fibrinogen (thrombinF). In the latter case liberation of fibrinopeptide A (FPA) was measured. Inactivation of thrombin was estimated by the difference between loss of thrombin from the solution and recovery of thrombin on the endothelial surface during the incubation with thrombin. Preincubation of the endothelium with AT or plasma increased the inactivation of both thrombinS and thrombinF but AT-free plasma had no such effect. Preincubation with heparin (5 IU ml) decreas-the inactivation of thrombin on the endothelium. Endothelial segments preincubated with AT caused a much more rapid inactivation of thrombin over time as compared to control segments. Aortic segments preincubated with heparin caused a slower inactivation of thrombin on the sruface as compared to control segments. It is concluded, that preincubation with AT enhances the inactivation of thrombin on the endothelium whereas preincubation with heparin has the opposite effect. Heparin causes liberation of endogenous AT from the endothelial surface which may explain the decreased inactivation on the surface in the latter case." @default.
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- W2888779963 date "1987-01-01" @default.
- W2888779963 modified "2023-09-23" @default.
- W2888779963 title "ROLE OF ANTITHROMBIN FOR INACTIVATION OF THROMBIN ON ENDOTHELIUM" @default.
- W2888779963 doi "https://doi.org/10.1055/s-0038-1643342" @default.
- W2888779963 hasPublicationYear "1987" @default.
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