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- W2888799368 abstract "Abstract Maladaptive learned behaviors are at the core of addiction. During drug use, addicts learn to associate their drug-taking activities with drug reward and environmental stimuli that eventually become cues that contribute to drug relapse. One important characteristic is that these drug-related cues and behaviors are nearly always complex and highly specific, such as recognizing specific drug-associated friends or environments. The second characteristic is that addicts still perform many other nondrug-related learned behaviors in their daily life. Animal models have been good at modeling these characteristics. As with addicts, drug-related cues and behaviors in these animal models can be complex and highly specific, and the animals can still perform many other nondrug-related learned behaviors. To date, the neuronal ensemble hypothesis is the only proposed neural mechanism with enough mechanistic resolution to encode complex highly specific learned behaviors and associations in human addiction and related animal models. This chapter covers what we currently know about neuronal ensembles in drug addiction research. We begin with a brief background about relevant animal models and techniques used to study them. We then describe the evidence supporting a causal role for neuronal ensembles encoding drug-related memories and behaviors in rat and mouse models; we sometimes supplement these studies with similar findings from food reward studies. We then describe unique molecular and cellular alterations found within neuronal ensembles that were activated during recall of drug-related memories. The long-term goal is to one day selectively target and manipulate molecular and cellular alterations induced within neuronal ensembles encoding addiction-related memories in human addicts." @default.
- W2888799368 created "2018-09-07" @default.
- W2888799368 creator A5054676202 @default.
- W2888799368 date "2019-01-01" @default.
- W2888799368 modified "2023-09-25" @default.
- W2888799368 title "Fos-Expressing Neuronal Ensembles in Addiction Research" @default.
- W2888799368 doi "https://doi.org/10.1016/b978-0-12-812202-0.00006-3" @default.
- W2888799368 hasPublicationYear "2019" @default.
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