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• W2888804988 abstract "Abstract Background Delivery of siRNA has been one of the major challenges to application of siRNA therapeutics. Polymer/lipid hybrid nanoparticles (HNPs) combine the advantages of both polymeric and liposomal carriers with remarkable properties for efficient siRNA encapsulation and delivery. Objective Herein, PLA-PEG-PLA/lipid hybrid nanoparticles were fabricated and utilized for siRNA encapsulation. Transfection efficiency of complex HNPs/siRNA was investigated in MCF7 breast cancer cells. Methods PLA-PEG-PLA copolymer was synthesized by ring opening polymerization and its hybridization with cationic lipid was performed using sonication method. Quality controls and HNP cytotoxicity were determined using DLS, AFM, SEM, and MTT assay, respectively. Cellular uptake of HNP/siRNA complex was investigated by flow cytometry and fluorescence microscope. Silencing activity of HNPs/siRNA complexes was analyzed using semi-quantitative RT-PCR. Results Fabricated HNPs exhibited improved biocompatibility compared to the cognate lipid nanoparticles and showed high siRNA encapsulation efficiency (80% ± 5). HNPs were capable of transferring of IGF-1R-siRNA into MCF7 cells, which resulted in expression down regulation of IGF-1R gene (70% ± 3). Conclusion The excellent cyto-compatibility, high cellular uptake, and remarkable gene silencing ability made HNPs promising carriers for efficient siRNA delivery." @default.
• W2888804988 created "2018-09-07" @default.
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• W2888804988 date "2018-12-01" @default.
• W2888804988 modified "2023-10-10" @default.
• W2888804988 title "Novel lipid-polymer hybrid nanoparticles for siRNA delivery and IGF-1R gene silencing in breast cancer cells" @default.
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• W2888804988 doi "https://doi.org/10.1016/j.jddst.2018.08.025" @default.
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