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• W2888887788 abstract "Skin-on-a-chip models are highly desirable in drug testing compared to conventional 2D cell culture and animal models as they can replicate organ-specific 3D structural organization and physiological functions at a relatively low cost. To engineer a physiologically relevant skin model, human skin structures have been integrated onto microfluidic platforms to construct skin-on-a-chip systems that can mimic the complex in vivo situation. In this mini-review, we first briefly introduce some critical technologies employed to develop in vitro skin-on-a-chip models. We then review the applications of the state-of-the-art skin-on-a-chip models in drug testing, with a focus on using models of full-thickness skin equivalents (FTSEs), skin models with additional components such as vasculature, immune cells and hair follicles as well as multi-organ-on-a-chip models. Finally, we discuss some current challenges and future directions of development of complex, and in vivo-like skin-on-a-chip models." @default.
• W2888887788 created "2018-09-07" @default.
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• W2888887788 date "2018-01-01" @default.
• W2888887788 modified "2023-09-30" @default.
• W2888887788 title "Current advances in skin-on-a-chip models for drug testing" @default.
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• W2888887788 doi "https://doi.org/10.21037/mps.2018.08.01" @default.
• W2888887788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7842276" @default.
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