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• W2888890021 abstract "Experimental limitations in measurements of coronary flow in the beating heart have led to the development of in silico models of reconstructed coronary trees. Previous coronary reconstructions relied primarily on anatomical data, including statistical morphometry (e.g., diameters, length, connectivity, longitudinal position). Such reconstructions are non-unique, however, often leading to unrealistic predicted flow features. Thus, it is necessary to impose physiological flow constraints to ensure realistic tree reconstruction. Since a vessel flow depends on its diameter to fourth power, diameters are the logical candidates to guide vascular reconstructions to achieve realistic flows. Here, a diameter assignment method was developed where each vessel diameter was determined depending on its downstream tree size, aimed to reduce flow dispersion to within measured range. Since the coronary micro-vessels are responsible for a major portion of the flow resistance, the auto regulated coronary flow was analyzed in a morphometry-based reconstructed 400 vessel arterial microvascular sub-tree spanning vessel orders 1 to 6. Diameters in this subtree were re-assigned based on the flow criteria. The results revealed that diameter re-assignment, while adhering to measured morphometry, significantly reduced the flow dispersion to realistic levels while adhering to measured morphometry. The resulting network flow has longitudinal pressure distribution, flow fractal nature, and near-neighboring flow autocorrelation, which agree with measured coronary flow characteristics. Collectively, these results suggest that a realistic coronary tree reconstruction should impose not only morphometric data but also flow considerations. The work is of broad significance in providing a novel computational framework in the field of coronary microcirculation. It is essential for the study of coronary circulation by model simulation, based on a realistic network structure." @default.
• W2888890021 created "2018-09-07" @default.
• W2888890021 creator A5045054117 @default.
• W2888890021 creator A5081782138 @default.
• W2888890021 creator A5088743713 @default.
• W2888890021 date "2018-08-29" @default.
• W2888890021 modified "2023-09-23" @default.
• W2888890021 title "Morphometric Reconstruction of Coronary Vasculature Incorporating Uniformity of Flow Dispersion" @default.
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• W2888890021 doi "https://doi.org/10.3389/fphys.2018.01069" @default.
• W2888890021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6123366" @default.
• W2888890021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30210353" @default.
• W2888890021 hasPublicationYear "2018" @default.
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